Lipid-based nanoparticle compositions are provided. The compositions generally comprise lipid-hydrophilic polymer-amyloid binding ligand conjugates, and may be liposomal compositions. The compositions, including the liposomal compositions, may be useful for imaging and/or the treatment of amyloid-尾 plaque ...
Lipid-based nanoparticles and methods using same The invention provides an improved lipid-based nanoparticle, which can be used to deliver a therapeutic agent to a subject, such as but not limited to a ma... WB Geho 被引量: 0发表: 2021年 Compositions comprising lipid-based nanoparticles for ...
Lipid-based nanoparticles are considered as promising candidates for delivering siRNA into the cytoplasm of targeted cells. However, in vivo efficiency of ... GH Dar,V Gopal,NM Rao - 《Molecular Pharmaceutics》 被引量: 3发表: 2014年 Augmented lipid-nanoparticle-mediated in vivo genome editing in...
PreciGenome offers high-performance Life Science Instrument & Solutions. We offer lipid nanoparticle LNP synthesis systems, PCR machines & assay, and microfluidic based systems include single-cell platform, cell perfusion system & droplet system, etc. Pr
Among these, lipid-based nanoparticles bear the advantage of being the least toxic for in vivo applications, and significant progress has been made in the area of DNA/RNA and drug delivery using lipid-based nanoassemblies. In this review, we will primarily focus on the recent advances and ...
Passive, active and endogenous organ-targeted lipid and polymer nanoparticles for delivery of genetic drugs 2023, Nature Reviews Materials Unlocking the promise of mRNA therapeutics 2022, Nature Biotechnology mRNA vaccine: a potential therapeutic strategy 2021, Molecular Cancer Lipid-based nanoparticles in ...
Folate-linked lipid- based nanoparticles deliver a NFκB decoy into activated murine macrophage-like RAW264.7 cells. Biol. Pharm. Bull. 2006, 29, 1516-... Y Hattori,M Sakaguchi,Y Maitani - 《Biological & Pharmaceutical Bulletin》 被引量: 45发表: 2006年 Folate-Linked Lipid-Based Nanoparticles...
Harnessing mRNA–lipid nanoparticles (LNPs) to treat patients with cancer has been an ongoing research area that started before these versatile nanoparticles were successfully used as COVID-19 vaccines. Currently, efforts are underway to harness this platform for oncology therapeutics, mainly focusing on...
Design of lipid-based nanoparticles for delivery of therapeutic nucleic acids Drug Discovery Today, Volume 28, Issue 3, 2023, Article 103505 Monique C.P. Mendonça,…, Caitriona M. O'Driscoll View PDF Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by var...
Yet, RNA-based therapeutics requires a delivery modality to facilitate the stability, uptake and intracellular release of the RNA molecules. The use of lipid nanoparticles as a drug delivery approach improves the payloads' stability, pharmacokinetics, bio-distribution and therapeutic benefit while ...