A high level of lipase in the blood is a sign that you may have a condition affecting the pancreas. It's likely that you have acute pancreatitis if your lipase levels are three to 10 times higher than the highest reference value. Elevated levels of lipase in your blood can also be a s...
The patient had a five-fold elevation of urinary amylase level and a slightly elevated serum lipa... T,L,F?rstr?m,... - 《Archives of Dermatology》 被引量: 41发表: 1975年 Lipase and pancreatic amylase activities in diagnosis of acute pancreatitis in patients with hyperamylasemia ...
The present study explored the high-level expression of RM lipase using superfolder green fluorescent protein (sfGFP)-mediated Escherichia coli secretion system. Results The sfGFP(−15) mutant was fused to the C-terminus of RM lipase to mediate its secretion expression. The yield of the fusion ...
In conclusion, the expression level of lipase MAS1 has been significantly elevated by chaperones co-expression and fermentation condition optimization. Besides VGB, co-expression of chaperones (PDI, BIP and HAC1) could promote the lipase MAS1 production. Lower induction temperature and pH 6.0 have ...
(Ahmad and Crandall, 2010) and therefore reducing the level of glycolytic products through the inhibition of lipase could be a solution.Orlistatis a commonly used anti-obesity drug. However, many of this type of drugs such asmazindol,dinitrophenol, andsibutraminehave affected the cardiovascular, ...
(Supplementary Fig.2b). Through PI uptake and LDH level assays, we confirmed that the decrease in cell viability was caused by necrotic cell death (Fig.1eand Supplementary Fig.2c, d). In addition, RSL3 induced cell death more efficiently when cells were plated at a low density, as ...
decreased post- heparin LPL activity was associated with elevated plasma triglyceride levels and lower levels of HDL-cholesterol,7,8 whereas decreased post-heparin HL activity was associated with slightly increased triglyceride and strongly increased HDL-cholesterol levels.8,9 Several common sequence variat...
Hence, the introduction of stable mutations in TLL pockets resulted in sustained higher activity at elevated temperature. Fig. 5 Comparison of enzymatic properties between wt–TLL and positive mutants (M11 and M21). a Optimum temperature for wt–TLL and the mutants M11 and M21. b Optimal pH ...
In humans, a change in HL activity is often associated with changes in the plasma level and composition of different lipoproteins, and with an increased or lowered risk of coronary artery disease (CAD). However, despite of extensive research during the last decade and the use of genetically ...
The triglyceride levels were also reduced in VLDL and IDL; however, the greatest reduction occurred in the LDL triglyceride level, which was 73% lower (P < 0.003) than in Ldlr−/− mice (Fig. 2B). Overexpression of catalytically inactive HL in the Ldlr−/−HLS145G mice reduced the...