1Origin Back in the 1970s several epithelial cell lines were established from gastrointestinal tumors. The purpose was to study mechanisms in cancer development and effects of cytotherapy. Partly due to the heterogeneity of primary intestinal epithelial cells both in morphology and function, i.e. sma...
Although Caco-2 cells have been found to express a large number of enzymes and transporter proteins present in normal human intestinal epithelium, recent studies suggest that there are variations between gene expression profiles of transformed epithelial cell lines like Caco-2, HT29 and normal human ...