连锁不平衡(Linkage Disequilibrium,LD)是指在基因组中,两个或多个SNP(单核苷酸多态性)位点在一个群体中的等位基因分布不符合期望的独立分布。也就是说,某些等位基因倾向于一起遗传,而不是独立分配。这种现象通常由于以下原因造成: ꔷ 物理距离:距离较近的SNPs更可能在同一条染色体上传递,形成较强的LD。 ꔷ ...
GWAS会漏掉很多点,所以才会有fine-mapping,根据haplotype来做一些imputation。 Linkage disequilibrium (LD)连锁不平衡:不同基因座位的各等位基因在人群中以一定的频率出现。在某一群体中,不同座位某两个等位基因出现在同一条染色体上的频率高于预期的随机频率的现象。(就是孟德尔的分离不是随机的,在染色体上越靠近的all...
J. (2018). A novel linkage-disequilibrium corrected genomic relationship matrix for SNP-heritability estimation and genomic prediction. Heredity 120 356.Mathew, B., Leon, J., and Sillanpaa, M. J. (2018). A novel linkage-disequilibrium corrected genomic relationship matrix for SNP-heritability ...
Existing SNP-heritability estimators that leverage summary statistics from genome-wide association studies (GWAS) are much less efficient (i.e., have larger standard errors) than the restricted maximum likelihood (REML) estimators which require access to
Linkage disequilibrium (LD)连锁不平衡:不同基因座位的各等位基因在人群中以一定的频率出现。在某一群体中,不同座位某两个等位基因出现在同一条染色体上的频率高于预期的随机频率的现象。(就是孟德尔的分离不是随机的,在染色体上越靠近的allele越倾向于绑在一起,属于物质性的限制。) 例如两个相邻的基因A B, 他们...
LINKAGE disequilibriumGENOME-wide association studiesLOW-rank matricesSTATISTICAL associationExisting SNP-heritability estimators that leverage summary statistics from genome-wide association studies (GWAS) are much less efficient (i.e., have larger standard errors) than the restricted maxi...
An Interactive Web Tool for Exploring Linkage Disequilibrium in Population Groupsldlink.nih.gov/ module LD express---Search if a list of variants (or variants in LD with those variants) is associated with gene expression in multiple tissue types. LD...
A basic knowledge on linkage disequilibrium (LD) is necessary in order to determine resolution of association studies. We investigated the extent and patterns of LD in a self-incompatible species (Prunus aviumL.), in 3 groups (wild cherry, sweet cherry landraces and sweet cherry modern varieties...
Linkage disequilibrium(LD), a term used in population genetics, indicates non-random association of alleles at two or more loci, not necessarily on the same chromosome. WikiMatrix 最受欢迎的查询列表:1K,~2K,~3K,~4K,~5K,~5-10K,~10-20K,~20-50K,~50-100K,~100k-200K,~200-500K,~1M...
词组短语 flux linkage[电]磁链;磁通匝连数 genetic linkage遗传连锁;基因连锁 linkage map连锁图 cross linkage交联;交键 steering linkage转向连杆;转向联动装置 linkage disequilibrium连锁不平衡 mechanical linkage机械联动装置 forward linkage前向联系;前向连锁;向前边锁率 ...