Linkage disequilibrium in two-stage marker-assisted selection. J Anim Breed Genet,1999, 116: 99--110Schulman N F ,de Vries M J ,Dentine M R. Linkage disequilibrium in two2stage marker2assisted selection. J Anim Breed Genet ,1999 ,116 : 99～110....
In practice, one typically has a sample of m chromosomes from the population. Then, estimates of r2 ( rˆ2) are usually obtained by plugging the sample frequencies πˆA, πˆB, πˆAB, etc., into equation (1). Besides estimating the amount of disequilibrium between pairs of marke...
Patterns of Linkage Disequilibrium (LD) across a genome has multiple implications for a population’s ancestral demography. For instance, population bottlenecks predictably result in increased LD, LD between SNP’s in loci under natural selection affect each others rates of adaptive evolution, selfing...
连锁不平衡(Linkage Disequilibrium,LD)是指在基因组中,两个或多个SNP(单核苷酸多态性)位点在一个群体中的等位基因分布不符合期望的独立分布。也就是说,某些等位基因倾向于一起遗传,而不是独立分配。这种现象通常由于以下原因造成: ꔷ 物理距离:距离较近的SNPs更可能在同一条染色体上传递,形成较强的LD。 ꔷ ...
The aim of this study was to better define the extent of linkage disequilibrium (LD) in populations of large-breed dogs and its variation by breed and chromosomal region. Understanding the extent of LD is a crucial component for successful utilization of genome-wide association studies and allows...
所以,最后的平衡称为连锁平衡linkage equilibrium,DAB(t)值称为连锁不平衡参数(linkage disequilibrium) 连锁平衡是在遗传过程中,不同基因座上的等位基因按照随机原则进行组合时,不同基因座的等位基因组合的频率等于组合等位基因各自频率的积,不存在优势组合。这种基因座间没有相关性的状态称为连锁平衡,此时连锁不平衡参...
Linkage disequilibrium in the human genome 来自 Nature 喜欢 0 阅读量: 212 作者:DE Reich,M Cargill,S Bolk,J Ireland,PC Sabeti,DJ Richter,T Lavery,R Kouyoumjian,SF Farhadian,R Ward 摘要: Nature is the international weekly journal of science: a magazine style journal that publishes full-...
et al. Extended haplotypes and linkage disequilibrium in the IL1R1–IL1A–IL1B–IL1RN gene cluster: association with knee osteoarthritis. Genes Immun 5, 451–460 (2004). https://doi.org/10.1038/sj.gene.6364107 Download citation Received20 February 2004 Revised08 April 2004 Accepted13 April ...
Table 2. The change in equilibrium causes an increment in parental rather than recombinant haplotypes. We can express the four haplotypes with the help of parameterization using D and r, such that D = r√P(A) P(B) P(A) P(b), where D is the disequilibrium, r is the correlation co...
Cannon, G.B., 1963, The effects of natural selection on linkage disequilibrium and relative fitness in experimental population ofDrosophila melanogaster. Genetics 48: 1201-1216. PubMedCASGoogle Scholar Cardon, L.R., Abecasis, G.R., 2003, Using haplotype blocks to map human complex trait loci....