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Legionella pneumophila, the etiological agent of Legionnaires’ disease was first recognized in 1976, during an outbreak of severe pneumonia at the convention of the American Legion in Philadelphia. Since then the genus Legionella has...
It has a spacer arm of 10.3 Å and connects lysine residues, which have a side chain length of 7.6 Å. Taking into account a protein in-solution flexibility of 10 Å, we hypothesized that the maximum labeling radius in our CLASP experiment (defined as the Cα-Cα distance...
The Thermo Scientific EZ-Link Desthiobiotinylation and Pull-Down Kit is a complete set of reagents to biotin-label purified proteins and use them to purify interaction complexes using streptavidin agarose resin with mild elution conditions.Features of the EZ-Link Desthiobiotinylation and Pull-Down Ki...
•Irreversible—forms permanent amide bonds; spacer arm cannot be cleaved •Long reach– spacer arm (total length added to target) is 29 angstroms; this reduces steric hindrance when binding to avidin molecules NHS-PEG4-Biotin is a long (29.0Å), pegylated, water-soluble, NHS-ester biotin...
Cleavable tethers contain a spacer and a structural feature designed to release the drug inside the cell called a “trigger.” The spacer is usually a short carbon chain for most ADCs but for some is a series of polyethylene glycol units, which are designed to reduce the logP of the linked...
proteins under native conditions, such as targeting intact cells or cell surface proteins. Sulfo-NHS-LC-Desthiobiotin is a variant of biotin that is activated as a sulfo-NHS ester with a long-chain (LC) spacer arm to covalently label primary amines (-NH2) of proteins or other molecules with...
Includes set of 4 The RSS Adjustable Rear Link Kit is the proper way to correct the rear suspension geometry of lowered 996 and 997 models when necessary. Greatly improves handling and feedback by removing rubber bushing deflection. Lowered vehicles with stock links may have additional negative ca...
• High-performance biotin reagent—Malemide-PEG2-Biotin uses efficient, sulfhydryl-specific maleimide chemistry and includes hydrophilic polyethylene glycol (PEG) spacer that stabilizes long-term solubility of labeled antibodies • Eight biotin-labeling experiments per kit—Thermo Scientific No-Weigh Pa...