The reaction types discussed in this chapter are proton transfer, substitution, oxidation–reduction, oxidative-addition, and isomerization. The development of a theoretical rate law and the effects of temperature and pressure on the rate constant are outlined. For proton transfer reactions, typical rat...
Author Correction: A dynamic three-step mechanism drives the HIV-1 pre-fusion reaction. Authors: Iliopoulou, Maro and Nolan, Rory and Alvarez, Luis and Watanabe, Yasunori and Coomer, Charles A and Jakobsdottir, G Maria and Bowden, Thomas A and Padilla-Parra, Sergi Journal: Nature structural...
This opens up new research routes, as methods based on mechanistic modeling, in the case of COBRA via the analyses of steady state solution spaces of biochemical reaction networks, are well suited for individualized phenotype predictions. This is because COBRA modeling does not rely on population ...
Reductionism is the philosophical idea that all higher-level (e.g. social, mental or medical) phenomena and processes can in principle be explained at a lower level (e.g. biology, chemistry, physics). Ontological reductionism states that all processes and events must ultimately be the result of...
PTEN regulates alternative splicing.aQuantification of E1A mRNA isoforms. A diagram of the E1A reporter gene indicating the alternative 5’ splice sites and splicing events that generate 13S, 12S and 9S mRNAs. The locations of the exon primers used for RT-PCR analysis are shown (top). RT-...
In response to a wound, fibroblasts are activated to migrate toward the wound, to proliferate and to contribute to the wound healing process. We hypothesize that changes in pre-mRNA processing occurring as fibroblasts enter the proliferative cell cycle a
Venn diagram showing unique and shared genes among main effect of age (A) or genotype (G), and their interaction (A × G).This diagram shows the number of differentially expressed (DE) genes that are common across contrasts and those that are unique to G (P≤0.05), A (P≤0.001), or...
Venn diagram showing unique and shared genes among main effect of age (A) or genotype (G), and their interaction (A × G).This diagram shows the number of differentially expressed (DE) genes that are common across contrasts and those that are unique to G (P≤0.05), A (P≤0.001), or...
Author Correction: A dynamic three-step mechanism drives the HIV-1 pre-fusion reaction. Authors: Iliopoulou, Maro and Nolan, Rory and Alvarez, Luis and Watanabe, Yasunori and Coomer, Charles A and Jakobsdottir, G Maria and Bowden, Thomas A and Padilla-Parra, Sergi Journal: Nature structural...
This chapter aims to discuss public health education, practice, and research-related issues in Thailand. Moreover, this chapter describes the achievements in education, practice, and research in the country. This chapter describes the challenges facing e