Edgotype: a fundamental link between genotype and phenotype. Curr Opin Genet Dev 2013;23(6):649-57.N. Sahni, S. Yi, Q. Zhong, N. Jailkhani, B. Charloteaux, M.E. Cusick, M. Vidal, Edgotype: a fundamental link between genotype and phenotype, Curr. Opin. Genet. Dev. 23 (2013...
Cornish-Bowden, A. and Cárdenas, M.L. 2000. From genome to cellular phenotype: a role for metabolic flux analysis? Nature Biotechnol. 18: 267–268. Google Scholar Cornish-Bowden, A. and Eisenthal, R. 2000. Computer simulations as a tool for studying metabolism and drug design. In: A....
Given the role of these molecules in cells, researchers have pointed to the metabolome as a key link between genotype and phenotype [3–5, 13–15]. Genetic variation clearly influ- ences the metabolome. For example, genome-wide associ- ation studies (GWAS) have identified alleles that ...
Using model organisms in an undergraduate laboratory to link genotype, phenotype, and the environmentmodel organismszebrafishCelegansundergraduateeducationWe developed laboratory exercises using zebrafish (Danio rerio) and nematodes (Caenorhabditis elegans) for a sophomore-level Integrative Biology Laboratory ...
By building on these technological breakthroughs, it may become possible in the future to bridge the genotype–phenotype gap and tackle the long-standing question of how diverse body plans are genetically encoded68. We provide EmbryoNet as open-source software, with Python packages, a GitHub ...
The stacked histograms display and calculate the ratio of immune cell infiltration in various sample groups within the GDM dataset. The gene expression matrix of the data set was merged to compute the correlation between immune cells and important genes in various groups of the RA dataset. ...
We designed GeneLink to facilitate the merging of our genotype data with pedigree and phenotype information (from either the Pedigrees table or the Trait Score table). This facilitates exporting data in formats commonly used in downstream analyses (e.g., GAS or LINKAGE format). There are three...
A chondrodysplasia family produced by mutations in the diastrophic dysplasia sulfate transporter gene: genotype/phenotype correlations Am J Med Genet, 63 (1996), pp. 144-147 View in ScopusGoogle Scholar 21 P. Kraulis A program to produce both detailed and schematic plots of proteins J Appl Crys...
Stress induced IL-1β: a potential link between stress and the development of visceral obesity Adipose tissue is comprised of a multitude of cells such as preadipocytes, mature adipocytes, mast cells, endothelial cells, fibroblasts and numerous types of immune cells [80,99]. Recent findings sugge...
Τhe importance of the gut microbiome and its functions has only recently been recognized and researched in greater depth. The establishment of the human gut microbiome begins in utero, forming its adult-like phenotype in the first 2–3 years of life. Several factors affect and alter the gut ...