Cornish-Bowden, A. and Cárdenas, M.L. 2000. From genome to cellular phenotype: a role for metabolic flux analysis? Nature Biotechnol. 18: 267–268. Google Scholar Cornish-Bowden, A. and Eisenthal, R. 2000. Computer simulations as a tool for studying metabolism and drug design. In: A....
Edgotype: a fundamental link between genotype and phenotype. Curr. Opin. Genet. Dev. 23, 649-657 (2013).Sahni N , Yi S , Zhong Q , Jailkhani N , Charloteaux B , Cusick ME , Vidal M ( 2013 ) Edgotype: a fundamental link between genotype and phenotype . Curr Opin Genet Dev ...
Edgotype: the link between genotype and phenotype Fiehn O. Metabolomics-the link between genotypes and phenotypes[J].Plant Molecular Biology,2002,(1-2):155-171.O. Fiehn, Metabolomics-the link between genotypes and phenotypes, Plant Mol. Biol. 48 (2002) 155-171... N Sahni,Y Song,Z Quan...
Edgotype: the link between genotype and phenotype Classical 'one-gene/one-disease' models cannot fully reconcile with the increasingly appreciated prevalence of complicated genotype-to-phenotype associations in human disease. Genes and gene products function not in isolation but as comp... N Sahni,...
The relationship betweengenotypeand phenotype is essential to understand how biological evolution proceeds. The distinction between the hereditary and developmental pathways as causally separated processes dates back to 1911 (Johannsen1911): the genome is inherited, while the phenotype is its final... ...
et al. De novo WNT5A-associated autosomal dominant Robinow syndrome suggests specificity of genotype and phenotype. Clin. Genet. 87, 34–41 (2015). 8. Grieshammer, U. et al. SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site. Dev. Cell 6, 709–717 (2004). 9....
elegans. This work describes a potential crosstalk between AD and HIV/AIDS via the cross-seeding between Aβ and SEVI, identifies SEVI as Aβ inhibitor for possible treatment or prevention of AD, and explains the role of SEVI in the gender difference in AD....
Using model organisms in an undergraduate laboratory to link genotype, phenotype, and the environmentmodel organismszebrafishCelegansundergraduateeducationWe developed laboratory exercises using zebrafish (Danio rerio) and nematodes (Caenorhabditis elegans) for a sophomore-level Integrative Biology Laboratory ...
and upregulate unique sets of genes that can either promote or hinder recovery depending on the immunological trigger. For instance, astrocytes seem to display a protective molecular phenotype during ischemic events, whereas their molecular phenotype seems to be harmful followingEscherichia coli(E. coli...
GenotypePhenotypeGenes, BacterialAlgorithmsInternetCarbohydrate Metabolismp pBackground/p pLinking phenotypes to high-throughput molecular biology information generated by ~omics technologies allows revealing cellular mechanisms underlying an organisms phenotype. ~Omics datasets are often very large and noisy with...