LINE-1 (L1 retrotransposon) constitutes a substantial portion of the human genome, and LINE-1 methylation correlates with global DNA methylation status. LINE-1 hypomethylation in colon cancer has been strongly
LINE-1 hypomethylation is widely accepted as marker for global genomic DNA hypomethylation, which is a frequent event in cancer. The aim of the study was to evaluate LINE-1 methylation status at different stages of gastric carcinogenesis and evaluate its prognostic potential in clinical settings. ...
Role of LINE-1 hypomethylation in CRC In 1992, cancer-associated with LINE-1 mutagenesis was reported when a somatic LINE-1 insertion into the APC gene was found to have caused a gene disruption in a colon cancer sample [50]. In a study by Lee et al., somatic LINE-1 insertions were ...
2 reagents referenced in LINE-1 hypomethylation in normal colon mucosa is associated with poor survival in Chinese patients with sporadic colon cancer.
L1s are active in the germ line and during embryogenesis,29,30 yet they are epigenetically suppressed in somatic cells.22,25 However, in line with L1 hypomethylation during tumorigenesis,31,32,33,34 L1s can be reactivated and may participate in the pathological processes of cancer initiation and...
in cancer; hypermethylation of gene promoters are frequently dis- covered in patients with cancer.8,19,20 In addition, the degree of LINE-1 hypomethylation was directly associated with a higher risk for developing a more aggressive cancer with poorer prognosis.9,12,13,21 Recently, a pattern of...
Precision of pyrosequencing assay to measure LINE-1 methylation in colon cancer, normal colonic mucosa, and peripheral blood cells. J Mol Diagn. 2010;12:177–83. 77. Iwagami S, Baba Y, Watanabe M, Shigaki H, Miyake K, Ida S, et al. Pyrosequencing assay to measure LINE-1 methylation ...
LONG INTERSPERSED NUCLEAR ELEMENTS (LINE-1) AND ALU HYPOMETHYLATION AS BIOMARKERS FOR COLORECTAL CANCER METASTASIS United States Patent Application 20120237929 Kind Code: A1 Abstract: A method for determining a colorectal cancer metastasis in a human subject suffering from a primary colorectal cancer (CRC...
The first case involved a gene-activating rearrangement at the MYC oncogene locus in breast ductal adenocarcinoma [21]. The second case involved a newly integrated L1 sequence that inactivated the APC tumor suppressor gene in colon cancer cells. This insertion had sequenc...
One recent report has shown that global LINE-1 hypomethylation can repress genome-wide gene expres- sion [22]. Alterations of LINE-1 methylation status have been observed frequently in some diseases, such as colon cancer [23], neural tube defects [24], and systemic lupus erythematosus [25]....