Lincosamides: chemical structure, biosynthesis, mechanism of action, resistance, and applications. Adv. Appl. Microbiol. 56:121-54; 2004. :Spizek, J., Novotna, J., and Rezanka, T. (2004) Lincosamides: chemical structure, biosynthesis, mechanism of action, resistance, and applications. Adv....
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Fu W, Anderson M, Williams S, Tait-Kamradt A, Sutcliffe J, Retsema J (2000)In vitroderived macrolide resistantStreptococcus pneumoniaestrains have ribosomal mechanism of resistance, abst. 07–10. In Program and abstracts of the 5th International Conference on Macrolides, Azalides, Streptogramins...
Conservation of the catalytic residues and that of the Mg2+ ion and the phosphate tail positioning all indicate a similar mechanism of action. As expected, residues responsible for the binding of clindamycin are not conserved because of great variation in the identity and the structure of second ...
Mechanism of action of spiramycin and other macrolides Resistance to macrolides in clinical isolates is most frequently due to post-transcriptional methylation of an adenine residue of 23S ribosomal RNA, which leads to co-resistance to macrolides, lincosamides and streptogramins type B (the... Bri...
Our structures, supported by extensive mutagenesis experiments, provide insight into the mechanism by which these distinct ARE-ABCFs displace antibiotics from their binding site on the ribosome to confer antibiotic resistance. Results Cryo-EM structures of in vivo formed ARE-ABCF-70S complexes To ...
Summary This chapter contains sections titled: Introduction Mechanism of Action Antibacterial Spectrum Resistance Pseudomembranous Colitis Next-Generation Lincosamides ConclusionsNatural Products in Medicinal Chemistrydoi:10.1002/9783527676545.ch07Hardwin O'Dowd...
[advances in applied microbiology] advances in applied microbiology volume 56 volume 56 || lincosamides: chemical structure, biosynthesis, mechanism of action, resistance, and applicationsSpížek, Jaroslav
The chapter provides information about the mechanism of action, antimicrobial activity, resistance, pharmacokinetic properties, drug interactions, toxicity and adverse effects, and administration and dosage of lincosamides, pleuromutilins, and streptogramins. It also discusses their clinical applications in ...
The streptogramin antibiotics: update on their mechanism of action. is under development for the treatment of severe infections caused by methicillin-resistant Staphylococcus aureus, methicillin-resistant Staphylococcus epidermidis, ... D,Beyer,K,... - 《Expert Opinion on Investigational Drugs》 被引...