In anyevent, clindamycin is superior to lincomycin for thetreatment of most infections for which these antibiotics areindicated.Lincomycin hydrochloride occurs as the monohydrate, awhite, crystalline solid that is stable in the dry state. It isreadily soluble in water and alcohol, and its aqueous ...
(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-D-erythro-a-D-galactooctopyranoside Monohydrochloride; Albiotic; C18H34N2O6S; Clindamycin Impurity 10; D-erythro-a-D-galacto-octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-...
(1) allergic to clindamycinmay also be allergic to clindamycin. (2) disturbance ofdiagnosis: serum alanine aminotransferase and aspartate aminotransferaseincreased after taking medicine. (3) the following should beused with caution: Intestinal diseases or thosewith previous history, such as ulcerative co...
As a result, compound 28 had potent antibacterial activities against major pathogens, which caused respiratory infections, even compared with clindamycin. On the other hand, compound 38 showed most potent activities against a variety of Streptococcus pneumoniae with erm gene. The Journal of Antibiotics...
were found more than twice as susceptible to clindamycin as to lincomycin.4) In experimental mice with staphyloc occal infection, clindamycin could achieve the same therapeutical effect as lincomycin with one tenth dose of the latter. This indicates an apparent parallelism between in vitro and in...
Like clindamycin, lincomycin is active against Gram-positive cocci and bacilli as well as Gram-negative cocci and some other organisms such as Haemophilus spp. Should azithromycin be taken on an empty stomach? If your doctor has prescribed azithromycin capsules, you should take them at least 1 ...
Lincomycin (LCM)13–16 was isolated as a secondary metabolite from the fermentation broth of Streptomyces lincolnensis. Clindamycin (CLDM)17 was synthesized by chemical modification of LCM and possessed a chlorine atom at the C-7 position with 7(S)-configuration. CLDM exhibited improved ...
As a result, compound 28 had potent antibacterial activities against major pathogens, which caused respiratory infections, even compared with clindamycin. On the other hand, compound 38 showed most potent activities against a variety of Streptococcus pneumoniae with erm gene....
(2) 1′-N-demethylclindamycin was twice as active in vitro against Sarcina lutea as CLDM, but 1′-N-demethyl- lincomycin was about one twentieth as active as LCM;21,44–45 (3) as for chain length (H, Me to octyl) at the 4′-position of LCM, the hexyl analog showed maximum in...
Clindamycin (CLDM) derived from lincomycin (LCM) is a useful semisynthetic antibiotic (Figure 1) that is effective against staphylo- coccal and streptococcal infections. However, those lincosamides show almost no antibacterial activity against resistant pathogens such as Streptococcus pneumoniae and ...