A robust definition of extreme environment is difficult to frame and is always contextually dependent on the object or person exposed to the environment and the subject of study. Most definitions with respect to the study of human medicine and biology incorporate the requirement for either ...
Transplantation of donor cells/tissues prior to the development of recipient immunocompetence theoretically provides the greatest opportunity to achieve donor specific tolerance (for our definition of key terms, such as tolerance, see Additional File 1). All of the tolerance processes that occur for se...
On the basis of our stringent definition of 'hits', all five factors validated in an alternate cell lineage, but the stringent definition likely resulted in multiple false-negatives. Importantly, we intentionally utilized shRNA-based knockdown NATURE COMMUNICATIONS | 8:15110 | DOI: 10.1038/ncomms...
Despite the success of therapies targeting oncogenes in cancer, clinical outcomes are limited by residual disease that ultimately results in relapse. This residual disease is often characterized by non-genetic adaptive resistance, that in melanoma is characterised by altered metabolism. Here, we examine...
On the basis of our stringent definition of 'hits', all five factors validated in an alternate cell lineage, but the stringent definition likely resulted in multiple false-negatives. Importantly, we intentionally utilized shRNA-based knockdown NATURE COMMUNICATIONS | 8:15110 | DOI: 10.1038/ncomms...
Cancer incidence increases with age and is a leading cause of death. Caloric restriction (CR) confers benefits on health and survival and delays cancer. However, due to CR’s stringency, dietary alternatives offering the same cancer protection have becom
A robust definition of extreme environment is difficult to frame and is always contextually dependent on the object or person exposed to the environment and the subject of study. Most definitions with respect to the study of human medicine and biology incorporate the requirement for either ...
Cancer incidence increases with age and is a leading cause of death. Caloric restriction (CR) confers benefits on health and survival and delays cancer. However, due to CR’s stringency, dietary alternatives offering the same cancer protection have becom