Biology Letters 11, 20150113.Smith C, Telemeco RS, Angilletta MJ, VandenBrooks JM. 2015. Oxygen supply limits the heat tolerance of lizard embryos. ... C Smith,RS Telemeco,MJ Angilletta,... - 《Biol Lett》 被引量: 12发表: 2015年 Oxygen supply limits the heat tolerance of avian em...
Myeloid cells mediated the pro-resolution function of Dectin-1 in EAE with enhanced gene expression of the neuroprotective molecule, Oncostatin M (Osm), through a Card9-independent pathway, mediated by the transcription factor NFAT. Furthermore, we find that the Osm receptor (OsmR) functioned ...
Earlier work has shown that short periods of very low caloric intake, including either periods of short-term fasting (2–4 days) or dietary manipulation of specific macronutrients, can be effective at delaying primary tumor growth4,5. Conversely, excess consumption of animal-derived protein is lin...
Despite the success of therapies targeting oncogenes in cancer, clinical outcomes are limited by residual disease that ultimately results in relapse. This residual disease is often characterized by non-genetic adaptive resistance, that in melanoma is characterised by altered metabolism. Here, we examine...
On the downside, Tregs also limit immune responses against tumors promoting the progression of cancer. Among the many mechanisms implied in Treg-mediated suppression, the inhibition of dendritic cells (DCs) has been shown to be central in peripheral tolerance induction as well as in cancers. We ...
On the basis of our stringent definition of 'hits', all five factors validated in an alternate cell lineage, but the stringent definition likely resulted in multiple false-negatives. Importantly, we intentionally utilized shRNA-based knockdown NATURE COMMUNICATIONS | 8:15110 | DOI: 10.1038/ncomms...
Persistent elevation of proinflammatory cytokines in the body can be defined as a risk factor that, either alone or in combination with other environment factors, may predispose to the loss of self-tolerance and the onset of T1DM-related autoantibodies. Adipose tissue functions are closely linked ...