Methods: Firstly, we downloaded the GC and glycolysis-related microarray datasets from TCGA and MSigDB databases and took the intersection to screen out the transcription factor LHX9 that regulates GC glycolytic metabolic reprogramming. Software packages were used for differential analysis, single gene ...
Interferon regulatory factor 7 regulates glioma stem cells via interleukin-6 and Notch signalling. Brain 2012; 135: 1055–1069. 12. Mao P, Joshi K, Li J, Kim SH, Li P, Santana-Santos L et al. Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde...
LHX6 is a LIM-homeobox transcription factor expressed during embryogenesis; however, the molecular mechanisms regulating LHX6 transcriptional activities are unknown. LHX6 and the PITX2 homeodomain transcription factor have overlapping expression patterns during tooth and craniofacial development, and in this...
The Co-IP analysis showed the presence of FHL2 in NFκB P65 immunoprecipi- tates, suggesting that FHL2 may function as a co-activator of NFκB transcription factor (Figure 7c). Similar, FHL2 was identified in c-Fos immunoprecipitates, suggesting that FHL2 also acts as a co-activator ...
The protein–protein interaction indicates regulation of Tbx function at the level of transcription factor nuclear localization. During chicken limb and heart development, Tbx5/LMP-4 and Tbx4/LMP-4 are tightly co-expressed in a temporal and spatial manner, suggesting that they operate in the same...
Guertl,B,Senanayake,U,Nusshold,E,Leuschner,I Mannweiler,S Ebner,B Hoefler,G. Liml,an embryonal transcription factor,is absent in multicystic renal dysplasia,but reactivated in nephroblastomas[J].Pathobiology:Journal of Immunopathology,Molecular and Cellular Biology,2011.210-219....
The transcription factor Myocyte enhancer factor 2C (MEF2C) plays a key role in the late differentiation of skeletal muscle progenitor cells, the so-called myoblasts. During myoblast differentiation, both MEF2C expression and transcriptional activity are regulated. We have reported that nTRIP6, the ...
L3, a novel murine LIM-homeodomain transcription factor expressed in the ventral telencephalon and the mesenchyme surrounding the oral cavity. Neurosci. Lett. 204: 113–116; 1996.Matsumoto K.; Tanaka T.; Furuyama T.; Kashihara Y.; Mori T.; Ishii N. et al. L3, a novel murine LIM-...
suggesting that FHL2 may function as a co-activator of NFκB transcription factor (Figure 7c). Similar, FHL2 was identified in c-Fos immunoprecipitates, suggesting that FHL2 also acts as a co-activator of AP-1 transcription factor (Figure 7d). Finally, we used chromatin immunoprecipitation ...
The LIM homeodomain (LIM-HD) transcription factor Isl1 was originally found to function as an insulin gene enhancer binding protein [21]. Isl1 is comprised of two tandem LIM domains and a homeodomain. The homeodomain, with its helix-turn-helix structure, binds to regulatory DNA sequences of ...