Several actin-binding proteins (ABPs) phase separate to form condensates capable of curating the actin network shapes. Here, we use computational modeling to understand the principles of actin network organization within VASP condensate droplets. Our sim
Tomich and coworkers attached either a nine (FLIVIGSII) or five residue (FLIVI) hydrophobic segment to the Ɛ- and α-amino group of N-terminal lysine of five lysine residue peptide (-K-K4) [20]. These peptides self-assembled to form nanovesicles in aqueous solution, while the linear...
Kiihner and co- workers44. Moreover, during the segregation, polymersomes’ membrane became thicker at the protrusions and thinner everywhere else, keeping the structure stable since the thick-walled compartments exhibit larger spontaneous curvatures than the thin-walled compartment. Fig. 5: The ...
The integrity of these two epithelial cells is maintained by the transmembrane proteins, such as claudins, occludins, and others. Gas (O2/CO2) transport and exchange is the primary function of lungs in the human body. In physiological conditions, the lungs exhibit excellent elastic characteristics...
Insulin receptor (IR) controls growth and metabolism. Insulin-like growth factor 2 (IGF2) has different binding properties on two IR isoforms, mimicking insulin’s function. However, the molecular mechanism underlying IGF2-induced IR activation remains u
Indeed, atopic dermatitis is an inflammatory skin disease caused by multiple factors, among which dysregulated type 2 immunity driven by Th2 cells plays a crucial role. Here, HIES including STAT3 deficiency and STAT3-related deficiency is also associated with activated Th2 responses and decreased ...
This period was followed by a plethora of studies assessing the efficacy of VLPs expressing HA, NA, or other influenza antigens on the surface of M1 proteins. The M2e antigen has been of considerable interest in influenza vaccine development. Fusing multiple copies of the M2 ectodomain has been...
This interpretation is further supported by recent findings from Selejan and coworkers who demonstrated upregulation of TLR2 in patients with cardiogenic shock and correlation of TLR2 expression with the “symptom to reperfusion time” [40]. Interestingly, the initial upregulation was followed by ...
targeting toll-like receptor signaling in plasmacytoid dendritic cells and autoreactive b cells as a therapy for lupus针对toll样受体信号在血浆树突细胞和autoreactive b细胞治疗红斑狼疮.pdf 11页VIP内容提供方:118zhuanqian 大小:569.15 KB 字数:约9.19万字 发布时间:2017-09-12发布于上海 浏览人气:3 ...
selected from the group consisting of the chosen sequence to a different nucleotide provided that no more than 15% of the nucleotides in the chosen coding sequence are so changed, an isolated second polynucleotide that is a complement of the first polynucleotide, or a fragment of any of them....