Fragmentation of nuclear DNA and loss of DNA integrity, occur progressively in the embryos of dry seeds. On imbibition, a loss of ability to repair DNA and an extended delay to DNA replication reflect the extent of genetic impairment. Changes in DNA ligase activity are central to these events...
What is the role of DNA polymerase during DNA synthesis? What is the function of topoisomerase in DNA replication? What role does DNA play in protein synthesis? What is the purpose of DNA sequencing? How does DNA ligase work? What is the primary function of DNA?
DNA replication occurs in the regions of the nucleus and forms new DNA strands. This process implies the synthesis of DNA from DNA. It requires a range of enzymes, each of which has a significant function. Answer and Explanatio...
DNA replication initiation is a two-step process. During the G1-phase of the cell cycle, the ORC complex, CDC6, CDT1, and MCM2–7 assemble at replication origins, forming pre-replicative complexes (pre-RCs). In S-phase, kinase activities allow fork establishment through (CDC45/MCM2–7/...
Cell Cycle DNA Replication E3 Ubiquitin Ligase Genomic Instability Protein Degradation Cdt1 FBXO31 Introduction FBXO31 was first identified as a candidate tumor suppressor gene located within the chromosome 16q24.3 loss of heterozygosity region in breast, ovarian, hepatocellular, and prostate cancers (...
DNA ligase IV Polyclonal Antibody 查看其他15个DNA Ligase IV抗体 说明书 实验方案 技术支持 货号PA5-28903 CNY4,181.00 100 µL 下单后预计有货时间 10-Mar-2025 查看价格 批量或定制请求 Application Created with Sketch. 图:1/4 DNA ligase IV Antibody (PA5-28903) in IHC (P)...
A tetrapyrrole-regulated ubiquitin ligase controls algal nuclear DNA replication. Nat Cell Biol 2011; 13:483-7.Kobayashi Y, Imamura S, Hanaoka M, Tanaka K (2011) A tetrapyrrole-regulated ubiquitin ligase controls algal nuclear DNA replication. Nat Cell Biol 13:483-487...
FACT plays important roles in both gene transcription and DNA replication. However, how this protein complex is targeted to these two distinct cellular processes remains largely unknown. Here we show that ubiquitylation of the Spt16 subunit of FACT by Rtt101, the cullin subunit of an E3 ubiquitin...
The presence of double-stranded DNA in the cytoplasm is a hallmark of viral/bacterial infection, retroviral replication, as well as cellular stress (which could also be caused by the release of mitochondrial DNA) and the production of cGAMP followed by STING activation, mediates as an innate ...
for the maintenance of genomic integrity by catalysing the formation of phosphodiester bonds between adjacent 5′-phosphoryl and 3′-hydroxyl termini at single and double strand breaks in duplex DNA molecules generated either directly by DNA damage or during replication, recombination, and DNA repair....