dBET6 是一种基于 PROTAC 的选择性和细胞渗透性 BET 降解剂,IC50值为 14 nM。 它具有抗肿瘤活性。 Apoptosis ¥ 397 现货 规格 数量 客户已引用 联系我们获取更多批次信息 资源下载 DataSheetSDS产品操作手册 TargetMol 的所有产品仅用作科学研究或药证申报,不能被用于人体,我们不向个人提供产品和服务。请您遵...
信号通路PROTACLigands for Target Protein for PROTACPROTAC BRD4 ligand-2 hydrochloride 顶部相关产品生物活性化学信息储存和溶解信息计算器PROTAC BRD4 ligand-2 hydrochloride 其他形式的 “PROTAC BRD4 ligand-2 hydrochloride”: PROTAC BRD4 ligand-2T396282154358-11-7 ...
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also called proteolysis-targeting chimeras(PROTACs),area new modality of chemical tools and potential therapeuticsto understand and treat human disease.Arequired PROTACcomponent isaligand binding to an E3 ubiquitin ligase, which is then joined to another ligand binding to a protein to be degradedvia ...
GPR17 is a hybrid G-protein-coupled receptor (GPCR) activated by two unrelated ligand families, extracellular nucleotides and cysteinyl-leukotrienes (cysteinyl-LTs), and involved in brain damage and repair. Its exploitment as a target for novel neuro-reparative strategies depends on the elucidation ...
Artificial intelligence-based protein structure prediction approaches have had a transformative effect on biomolecular sciences. The predicted protein models in the AlphaFold protein structure database, however, all lack coordinates for small molecules,
The enzyme responsible for the addition of an α2,8-linked Neu5Ac on O-glycans has been shown to be human α2,8-sialyltransferase-VI and its expression level is enhanced in a human lung (www.proteinatlas.org). We speculate that a human lung may be armed with a huge number of tissue...
The increase in antibiotic-resistant strains of pathogens has created havoc worldwide. These antibiotic-resistant pathogens require potent drugs for their inhibition. Lipopeptides, which are produced as secondary metabolites by many microorganisms, have the ability to act as potent safe drugs. Lipopeptides...
Importantly, E3 ubiquitin ligases (more than 700 are known in humans) confer substrate specificity to the protein ubiquitination pathway, making this enzyme a very attractive target for specific and less toxic therapeutic treatment, reducing side effects that can be related with other U...
Cyclic peptides are able to bind with high affinity and target specificity to protein targets and hence are an attractive molecule class for the development of therapeutics. In fact, several cyclic peptides are already successfully used in the clinic, as for example the antibacterial peptide vancomy...