Structural Insights into Ligand-Induced Degradation of Estrogen Related Receptor AlphaScott A. Lawrence
the B-1 cells responses to or isolated from parasites remain poorly characterized EVs. Learning the activation and differentiation of B-1 cells can donate to a better knowledge of how these cells take part in immunity to Hence, we examined the...
Ligand-Induced Degradation of a CAR Permits Reversible Remote Control of CAR T Cell Activity In Vitro and In Vivo Molecular Therapy, Volume 28, Issue 7, 8 July 2020, Pages 1600-1613 Sarah A. Richman, Liang-Chuan Wang, Edmund K. Moon, Uday R. Khire, Steven M. Albelda, Michael C. Mil...
29kAccesses 45Altmetric Metrics Abstract Heterobifunctional small-molecule degraders that induce protein degradation through ligase-mediated ubiquitination have shown considerable promise as a new pharmacological modality. However, we currently lack a detailed understanding of the molecular basis for target recr...
Sensitivity to Flg22 is modulated by ligand-induced degradation and de novo synthesis of the endogenous flagellin-receptor FLAGELLIN-SENSING2. Plant Physiol. 164, 440–454 (2014). Article CAS Google Scholar Lu, D. et al. Direct ubiquitination of pattern recognition receptor FLS2 attenuates plant...
and involves ubiquitination of the receptor. Targeting of receptors for degradation requires members of the Cbl gene family. Cbl proteins bind to tyrosine phosphorylated EGF receptor, and are E3 ubiquitination ligases that label receptor for degradation. Cbl also recruits Cin85 to the receptor complex...
Inducing protein degradation via small molecules is a transformative therapeutic paradigm. Although structural requirements of target degradation are emerging, mechanisms determining the cellular response to small-molecule degraders remain poorly understood. To systematically delineate effectors required for targeted...
Leslie, M.E., Heese, A. (2014). A Re-elicitation Assay to Correlate flg22-Signaling Competency with Ligand-Induced Endocytic Degradation of the FLS2 Receptor. In: Otegui, M. (eds) Plant Endosomes. Methods in Molecular Biology, vol 1209. Humana Press, New York, NY. https://doi.org/10...
Ligand-induced down-regulation of the type I interferon receptor represents a major mechanism of negative regulation of signaling and involves internalization and lysosomal degradation of IFNAR1. Interferon {alpha} promotes phosphorylation of IFNAR1 on serine 535, followed by recruitment of the {beta}...
Lee KH, Dinner AR, Tu C, et al. The immunological synapse balances T cell receptor signaling and degradation. Science. 2003;302: 1218-1222. Zal T, Zal MA, Gascoigne NR. Inhibition of T cell receptor-coreceptor interactions by antagonist ligands visualized by live FReT imaging of the T-hybr...