1991. The role of kinase activity and the kinase insert region in ligand-induced internaliza- tion and degradation of the c-fms protein. EMBO J. 10:877-883.CARLBERG K ET AL: "THE ROLE OF KINASE ACTIVITY AND THE KINASE INSERT REGION IN LIGAND-INDUCED INTERNALIZATION AND DEGRADATION OF THE...
Heterobifunctional small-molecule degraders that induce protein degradation through ligase-mediated ubiquitination have shown considerable promise as a new pharmacological modality. However, we currently lack a detailed understanding of the molecular bas
Sensitivity to Flg22 is modulated by ligand-induced degradation and de novo synthesis of the endogenous flagellin-receptor FLAGELLIN-SENSING2. Plant Physiol. 164, 440–454 (2014). Article CAS Google Scholar Lu, D. et al. Direct ubiquitination of pattern recognition receptor FLS2 attenuates plant...
Coexpression of p75 NTR attenuated ubiquitination of TrkA and TrkB and delayed nerve growth factor-induced TrkA receptor internalization and receptor degradation. These results indicate that p75 NTR may prolong cell-surface Trk-dependent signalling events by negatively regulating receptor ubiquitination. ...
and involves ubiquitination of the receptor. Targeting of receptors for degradation requires members of the Cbl gene family. Cbl proteins bind to tyrosine phosphorylated EGF receptor, and are E3 ubiquitination ligases that label receptor for degradation. Cbl also recruits Cin85 to the receptor complex...
Ligand-induced down-regulation of the type I interferon receptor represents a major mechanism of negative regulation of signaling and involves internalization and lysosomal degradation of IFNAR1. Interferon {alpha} promotes phosphorylation of IFNAR1 on serine 535, followed by recruitment of the {beta}...
We conclude that the enhanced EGFR recycling that has been observed in HER-14 cells following TGF伪 or E4T stimulation correlates with decreased EGFR ubiquitination and EGFR degradation, and that proteasomal activity is required for de-ubiquitination of the EGFR prior to its lysosomal degradation....
Functional properties of leptin receptor isoforms: internalization and degradation of leptin and ligand-induced receptor downregulation. Uotani S,Bjorbaek C,... S Uotani,C Bjorbaek,J Tornoe - 《Diabetes》 被引量: 0发表: 1999年 Barriers for lateral diffusion of transferrin receptor in the plasma...
The receptor sequence terminated at Ala316 (Fig. S1) as this construct is degradation resistant [25] and has been used extensively in structural studies, having wild-type pharmacology [26,27]. Prior to SMA-extraction, cells were disrupted following suspension in breaking buffer (50 mM sodium–...
In water, QDs also may generate hydroxyl radicals which also can be responsible for the degradation of the dyes. Therefore, CdS QDs might be used as potential photocatalyst to effectively treat the organic pollutants under visible light irradiation. Taking into account enantioselectivity of adsorption ...