ligand-binding pocke来自t是什么意思ligand-bi客距化妒振nding pocket 配体结合口袋 双语例句 We sugges...
我们推测位于疏水性口袋结构处的疏水性氨基酸参与了气味化合物的最初识别，并与化学感受蛋白的特异性结合有关。ligand-binding pocket配体结合口袋
tobethebindingpocketoftheligand •Identifythelocationandshapeof potentialligandbindingpocket -SURFNET:identifyclefts -ConSurf-HSSP:trimSURFNETidentified clefts,identifypotentialbindingpockets SURFNET •Buildupgapby fittingspheres intothespaces betweenatoms ...
Putative ligand-binding pocket.Pascale SchellenbergerClaude SauterBernard LorberPatrick BronStefano TrapaniMarc BergdollAurélie MarmonierCorinne SchmittKeichingerOlivier LemaireGérard Demangeat
These methods generally rely on first identifying a ligand-binding pocket in the protein structure. Finding a comprehensive, fast and automated method that can accurately predict ligand-binding pockets on protein surfaces is a major challenge in virtual screening biophysics. This goal leads us to ...
N-terminus, ECL2 and ECL3 were predicted to constitute the peptide binding pocket AST-C peptide, the putative ligand of CamAlstR-C, was docked onto the receptor more than 100 times. The most probable docking region (I) contributed to 57% of the docking poses (Fig. 3a). The binding poc...
Nuclear receptor-related 1 protein (Nurr1/NR4A2) is an orphan nuclear receptor (NR) that is considered to function without a canonical ligand-binding pocket (LBP). A crystal structure of the Nurr1 ligand-binding domain (LBD) revealed no physical space in the conserved region where other NRs...
The VDR binds its ligand with extremely high affinity, in the range of 10−10M. The ligand-binding pocket (LBP) comprises many segments spanning the entire C-terminal domain of 300 amino acids [43]. Great progress in understandingligand bindingand in identifying the crucial amino acids came ...
(CRD1, CRD2 and CRD3) characteristic of TNF R superfamily members and a less conserved, fourth cysteine-rich domain that is membrane-proximal.5CRD2 and CRD3 form the ligand binding pocket for TNF-alpha.5Previous studies have shown that TNF R superfamily signaling may be induced upon ligand...
(2003) Structural adaptability in the ligand-binding pocket of the ecdysone hormone receptor. Nature 426: pp. 91-96 CrossRef Bondi, A. (1964) van ... Y Nakagawa,RE Hormann,G Smagghe - Springer Netherlands 被引量: 9发表: 2009年 Adaptability of the ecdysone receptor bound to synthetic ligan...