# 4. Perform NicheNet ligand activity analysisligand_activities<- predict_ligand_activities(geneset = geneset_oi,background_expressed_genes= background_expressed_genes,ligand_target_matrix= ligand_target_matrix,potential_ligands= potential_ligands)ligand_activities<- ligand_activities %>% arrange(-aupr_...
$ligand_activity_target_heatmap: heatmap showing both ligand activity scores and target genes of these top ligands; $ligand_receptor_matrix: matrix of ligand-receptor interactions; $ligand_receptor_heatmap: heatmap showing ligand-receptor interactions; $ligand_receptor_df: data frame of ligand-recep...
Polymer matrix nanocomposites filled with metallic and alloy nanoparticles add functionality in various applications such as optical devices and in the energy sector. However, matrix coupling agents or nanoparticle ligands may be unwanted additives, potentially inhibiting the resulting nanocomposite to be pro...
Ligand-binding assays (LBAs) used in the quantification of biotherapeutics for pharmacokinetic determinations rely on interactions between reagents (antibodies or target molecule) and the biotherapeutic. Most LBAs do not employ an analyte extraction procedure and are susceptible to matrix interference. Here...
Ligand-based peptide design and combinatorial peptide libraries to target G protein-coupled receptors. G protein-coupled receptors (GPCRs) are considered to represent the most promising drug targets; it has been repeatedly said that a large fraction of the c... Christian,W,Gruber,... - 《Curre...
If one groups targets in columns and ligands in rows, chemogenomic approaches to drug discovery just fill the interaction matrix. Since experimental data do not suffice, several computational methods are currently actively developed to supplement time-consuming and costly experiments. They are either ...
TGF- isoforms (TGF-1, -2, and -3) are secreted signaling ligands that stimulate the expression of protein components of the extracellular matrix, regulate the growth and differentiation of epithelial cells, modulate immune cell function, and play roles in the development of several essential organs...
# 4. Perform NicheNet ligand activity analysisligand_activities<- predict_ligand_activities(geneset = geneset_oi,background_expressed_genes= background_expressed_genes,ligand_target_matrix= ligand_target_matrix,potential_ligands= potential_ligands)ligand_activities<- ligand_activities %>% arrange(-aupr...
Zinc-dependent matrix metalloproteinase (MMP) family is considered to be an attractive target because of its important role in many physiological and patho... L Xi,J Du,S Li,... - 《Journal of Computational Chemistry》 被引量: 26发表: 2010年 Receptor- and ligand-based 3D-QSAR study for ...
Additionally, the SCA can also be used for the construction of antibody based fusion proteins to target other effector functions to tumour cells.P... P,Savage,G,... - 《British Journal of Cancer》 被引量: 16发表: 1993年 Nanobodies and Nanobody-Based Human Heavy Chain Antibodies As Antitum...