Protein-ligand interactions are essential for a variety of biological processes, such as interactions in antibody-antigen recognition [3], cell-cell communication [5], and signal transduction [6]. Abnormal interactions can lead to many diseases, so it is important to gain a thorough understanding ...
mitochondria, and promotes cell death. This combinatorial platform technology has potential applications in cell biology and drug development. Introduction For more than a decade,in vivophage display has allowed identification of novel peptide ligands that selectively target blood vessels of normal organs ...
In this study, ligand-modified nanoparticles based on human serum albumin (HSA) were developed and optimized for an efficient gene therapy. Different glutaraldehyde cross-linking degrees were investigated to optimize the HSA nanoparticles for gene delivery. The peptide sequence arginine-glycine-aspartate ...
Developmental changes in the electrophysiological properties and response characteristics of Manduca antennal-lobe neurons Using whole cell patch-clamp recordings, we have examined changes in the electrophysiological properties and response characteristics of antennal lobe (AL)... AR Mercer,JG Hildebrand 被引...
Detecting ligand-protein interactions in living cells is a fundamental challenge in molecular biology and drug research. Proteome-wide profiling of thermal stability as a function of ligand concentration promises to tackle this challenge. However, current data analysis strategies use preset thresholds that...
One of the first molecules targeted by mAbs was the epidermal growth factor receptor (EGFR), which plays a crucial role in cell proliferation, differentiation, survival, angiogenesis, and metastasis [224]. Overexpression of EGFR protein is frequently found in many different tumors such as lung, br...
[1]. Hofbauer LC, et al. Role of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin in bone cell biology. J Mol Med (Berl). 2001 Jun;79(5-6):243-53. [2]. Ono T, et al. RANKL biology: bone metabolism, the immune system, and beyond. Inflamm Regen. 2020 Feb ...
The role of Th2 type CD4+ T cells and Th2 type CD8+ T cells in asthma. The cellular inflammatory responses which are seen in allergic and asthmatic diseases are viewed as being quite strongly dependent on the activities of T c... KJ Erb,GL Gros - 《Immunology & Cell Biology》 被引...
in rat testis, Ob-R expression is characteristic of mature Leydig cells (fetal and adult type) and it is functional in adult but not prepubertal life... M Caprio,E Fabbrini,G Ricci,... - 《Biology of Reproduction》 被引量: 110发表: 2003年 Spatial expression of Cbfa1/Runx2 isoforms in...
Lipids in cell biology: how can we understand them better? Mol. Biol. Cell, 25 (2014), pp. 1819-1823 View in ScopusGoogle Scholar Mutoh et al., 2012 T. Mutoh, R. Rivera, J. Chun Insights into the pharmacological relevance of lysophospholipid receptors Br. J. Pharmacol., 165 (2012),...