NR supplementation attenuates the development of heart failure in a mouse model of dilated cardiomyopathy (Diguet et al., 2017), and stimulates hematopoiesis through increased mitochondrial clearance in immunodeficient mice (Vannini et al., 2019). In humans, a recent clinical trial showed that ...
The fight or flight response is well known for having broad effects throughout the body, including causing increased heart rate and slowed digestion. As part of this response, the researchers found that the neurons in the hypothalamus set off a chain of events that triggers neurons that governw...
Among 221,962 transplant recipients, 13,074 (5.9%) developed cancer within 10 years of transplantation. During this 10-year post-transplant period, recipients who developed cancer lost an average of 2.7 years of life due to their cancer diagnosis. In total, cancer was responsible for 11% of ...
CardioPulse ArticlesPushing the boundaries of science in a changing landscapeThe ambitions and goals of the National Heart, Lung, and Blood Institute at Th... Prostate cancer ( PCa ) is one of the commonest cancers in men and a major cause of cancer-related mortality. Family history is the...
Summarizes sex-based differences in epidemiology and pathophysiology of cardiotoxicity related to with anthracyclines, hematopoietic stem cell transplant, hormone therapy, and immune therapy. • Ohman RE, Yang EH, Abel ML. Inequity in cardio-oncology: identifying disparities in cardiotoxicity and links ...
These EOD effects often appeared to be more pronounced in the young group than in the aged set of animals. In sum, EOD effects were consistent with a retardation of heart growth (particularly evident in the young group) and consequently reductions in heart dimensional measures described above....
Heart Research Institute, The University of Sydney, Sydney, New South Wales, Australia John O’Sullivan & Yen Chin Koay Department of Medical Biology, The Arctic University of Tromsø, Tromsø, Norway Gunbjorg Svineng School of Biological Sciences, Monash University Clayton Campus, Melbourne, Vic...
The impact of nephrolithiasis on skeletal growth and bone health across the life span of kidney stone formers is reviewed. Bone disease is an early event a
The successful transfer of a gene that produces HMW-HA paves the way for improving the health and lifespan of humans, too. In a groundbreaking endeavor, scientists at theUniversity of Rochesterhave successfully transferred a longevity gene from naked mole rats to mice, ...
Elimination of senescent cells (senolysis) was recently reported to improve normal and pathological changes associated with aging in mice1,2. However, most senolytic agents inhibit antiapoptotic pathways3, raising the possibility of off-target effects in normal tissues. Identification of alternative senoly...