which develop the senescence-associated secretory phenotype (SASP). Here we show that procyanidin C1 (PCC1), a polyphenolic component of grape seed extract (GSE), increases the healthspan and lifespan of mice t
Discerning the relationship between sociality and longevity would permit a deeper understanding of how animal life history evolved. Here, we perform a phylogenetic comparative analysis of ~1000 mammalian species on three states of social organization (so
The capacity to rapidly extract and process visual information is critical for the successful completion of a range of everyday activities, and as a result, substantially influences quality of life. Visuospatial processing speed is a core cognitive function that underlies a variety of other processes,...
The impact of nephrolithiasis on skeletal growth and bone health across the life span of kidney stone formers is reviewed. Bone disease is an early event a
Self-management includes all behavioural measures and cognitive activities aimed at coping with challenges arising throughout the lifespan. While virtually all of these challenges can be met without pharmacological means, alcohol consumption has long been instrumentalized as a supporting tool to help copi...
Note that female survival surpassed male survival in every year at both the beginning of life and later in life. Source: human mortality database. It used to be thought that women’s survival advantage began at conception and was robust in utero as well (Austad, 2011). However, extensive ...
RTX, the chimeric prototype, has been in use for more than a decade in this indication.26 Although newer, fully humanized antibodies such as ofatumumab hold theoretical advantages, a recent study found no clinical benefit with regard to maintenance of remission at 1 year in a cohort with ...
500-600 mL urine at 2 years old, Begin voluntary control Toddler: Gastrointestinal Functional maturity, Needs more frequent meals/snacks, Control of internal/external anal sphincters Toddler: Respiratory Lung capacity increases, Respiratory rate decreases, ...
Over the past few decades, neuroimaging has become a ubiquitous tool in basic research and clinical studies of the human brain. However, no reference standards currently exist to quantify individual differences in neuroimaging metrics over time, in contr
a high number of general worry or depressive symptoms, and diminished performance in executive functioning33,34. In sum, beliefs of inevitable memory decline with age are associated with beliefs regarding increased dependency in old age, decreased performance on memory tasks, and increased fear of ...