Clozapine is regarded as a second-line and in some cases last-line antipsychotic known for its common life-threatening side effects, such as agranulocytosis, constipation and cardiomyopathies, but rarely haematemesis. We report a case of severe haemetemesis in a chronic schizophrenic patient man...
Clozapine was gradually reintroduced with concurrent laxative administration, which resulted in another episode of severe constipation with faecal impaction. Clozapine can be associated with potentially life-threatening constipation. Psychiatrists, especially consultation liaison psychiatrists, physicians, surgeons ...
The aim of this paper was to describe the association of clozapine with life-threatening constipation. Case report. A 53-year-old man presented to the emergency department with severe abdominal pain and bilious vomiting after being on clozapine for over a year for schizoaffective disorder. Surger...
But of course, all medications haveside-effectsand for some people on antipsychotics theseside-effectscan range frommildly debilitating to life threatening. One such drug, clozapine—often reserved fordifficult to treat cases of schizophrenia– can lower people's white blood count to dangerous levels ...
Clozapine N-oxide (CNO) was administered via intraperitoneal (IP) injection at a dose of 1 mg/kg 30 min prior to startle testing such that CeAL CRF + neurons would be persistently silenced throughout the startle testing session. Fig. 3: CeAL CRF+ neurons were necessary for within-...
The aim of this article is to comprehensively and critically review the recently published evidence with regard to drug-induced life-threatening arrhythmias and sudden cardiac death. It will take into account the provision of data to physicians that are useful in the identification of the culprit dr...
Fecal microbiota transplants (FMT) pose a risk of serious or life-threatening adverse events likely because of transmission of pathogenic organisms, the US Food and Drug Administration (FDA) warns in a new safety communication. The FDA said it is aware of infections caused by enteropathogenic ...
spinning or dizziness, is usually caused by problems involving the inner ear (peripheral vertigo) or, less commonly, the central nervous system (central vertigo). Seeking medical attention quickly for sudden unexplained vertigo is essential, as stroke is an uncommon but life-threatening cause of ...
Fear is evoked when the brain perceives life-threatening danger, having evolved to induce behavioral and physiological responses that increase the survival chances of individuals10,11,12. However, protective effects conferred by fear remain unclear. Elucidating these effects is important not only for ...
(Fig.3a). Following a 3–4-week recovery, mice underwent startle testing 24 h. after cued-fear conditioning. Clozapine N-oxide (CNO) was administered via intraperitoneal (IP) injection at a dose of 1 mg/kg 30 min prior to startle testing such that CeAL CRF + neurons would be...