cancer (a chestnut–like flattened shape); C – cancer of the left kidney (the shape of a bean); D – the lactation state; E – gastrointestinal cancer; F – the shoulder malfunctioning (complex elongated shape); G – lung cancer, advanced stage; H – colorectal cancer (terminal sta...
In this study, we characterized the global kidney miRNA expression profile in untreated male and female F344 rats throughout the life span. These findings were correlated with sex-specific susceptibilities to adverse renal events, such as male-biased renal fibrosis and inflammation in old age. ...
However, the patterns and explanations of variations in sex disparities in mortality across the life span and underlying causes of death are not well understood. We conducted a population-based study to further test this hypothesis. Methods By using a nationally representative sample of adults (N ...
Spermidine, a naturally occurring polyamine, extends the lifespan of mice and is cardioprotective in both aged mice and hypertensive rats. In humans, high dietary spermidine intake is associated with reduced blood pressure and a lower incidence of cardio
For healthspan and lifespan, ERK, AMPK and mTORC1 represent critical pathways and inflammation is a centrally important hallmark1–7. Here we examined whether IL-11, a pro-inflammatory cytokine of the IL-6 family, has a negative effect on age-associated
Pharmacological attenuation of mTOR presents a promising route for delay of age-related disease. Here we show that treatment of Drosophila with the mTOR inhibitor rapamycin extends lifespan in females, but not in males. Female-specific, age-related gut p
Life extension refers to an increase in maximum or average lifespan, especially in humans, by slowing down or reversing the processes of aging. Average lifespan is determined by vulnerability to accidents and age-related afflictions such as cancer or cardiovascular disease. Extension of average ...
Gonadal ageing correlates with comorbidities and an increased risk of age-related diseases including diabetes, kidney problems, cardiovascular failures and cancer. This article briefly summarizes the current state of knowledge on ovarian and testicular senescence, explores the experimental models used in ...
The leukaemia and brain cancer risk estimates resulting from the UK and Australian studies were larger than the estimates obtained using the latest Life Span Study data (Hsu et al., 2013; Preston et al., 2007). At present, methodological limitations such as the inclusion of patients with ...
That was what it was like to be Amanda Garbatini, now 32. Over a 20-year time span, she was treated at Yale New Haven Children's Hospital and Smilow Cancer Hospital for rhabdomyosarcoma; chondrosarcoma, which claimed part of her right lung and a rib; clear-cell carcinoma of the kidney...