et al. Social stress shortens lifespan in mice. Aging Cell 17, e12778 (2018). Article PubMed PubMed Central CAS Google Scholar Carroll, J. E. et al. Partial sleep deprivation activates the DNA damage response (
A prospective double-blind randomized crossover study was done in 15 patients with complete heart block and intermittent ATs. The pacemaker was randomly programmed to dual chamber inhibited rate responsive pacing (DDIR) and to DDDR with mode switch, for 1 month each. An event recorder was ...
Ageing-associated functional decline of organs and increased risk for age-related chronic pathologies is driven in part by the accumulation of senescent cells, which develop the senescence-associated secretory phenotype (SASP). Here we show that procyanidin C1 (PCC1), a polyphenolic component of grap...
To quote J.D. Bernal (1959): “There is only one dominant chemical pattern of life. If more than one exists the others must be obscure, as are some of the red algae, and unnecessary to the survival of the dominant”, and “We may define life, for the...
The last day to order the affected product(s) is February 3, 2025. Customers with active service contracts will continue to receive support from the Cisco Technical Assistance Center (TAC) as shown in Table 1 of the EoL bulletin. Table 1 describes the end-of...
A 15-pound wild turkey living in Forest Park owed its survival Tuesday to a Humane Society officer, a veterinarian, a zoo curator and several of St. Louis' finest. "I've been messing with this thing for two hours," said Officer Michael Larkin, who patrols the park. "He kept going bac...
doi:10.1002/ddr.20077Patrick MarquisBenoit ArnouldCatherine AcquadroW. Mark RobertsJohn Wiley & Sons, Ltd.Drug Development ResearchMarquis P, Arnould B, Acquadro C, Roberts WM: Patient-reported outcomes and health-related quality of life in effectiveness studies: pros and cons. Drug Development ...
2. Discoidin domain receptor 1 as a potent therapeutic target in solid tumors hLife | DDR1:新兴实体瘤微环境调控靶点 通讯作者:金腾川 文章讨论了人类跨膜蛋白盘状蛋白结构域受体1(DDR1)的结构、功能和病理特征,逐步揭示了DDR1在实体瘤微环境中的作用,并提出了其作为潜在的治疗靶点的可行性。
It plays a crucial role in the cell energy metabolism, amino acid/protein synthesis, epigenetic regulation, stemness and differentiation, fertility and reproductive health, and cancer cell behaviors. AKG exerts its effects through different mechanisms such as inhibiting mTOR and ATP-synthase, modulating...
(SGT); both processes are referred to as MET and EMT in cancer; (iii) Oxygen-sensitive germlines that irreversibly lose their reproductive function due to irreparable DNA damage caused by excess oxygen; (iv) DNA damage repair (DDR) mechanisms to repair DNA replication and polyploidization ...