lichen sclerosusvulvar cancercancer riskMalignant potential of lichen sclerosus (LS) has been suspected, but evidence is sparse. We used the population-based Finnish Cancer Registry data to further study this connection.International Journal of Cancer =: Journal International du Cancer...
Lichen sclerosus (LS) is a chronic inflammatory disease affecting skin and mucosal tissues, particularly external genitalia, with a risk of cancer. Its etiology is unknown, possibly involving immune dysregulation and inflammation. Methods Study used DNA methylation (DNAme) and single-cell RNA sequencing...
Prognosis of Lichen Sclerosis: There is an increased risk of cancer in the long term; women with Lichen Sclerosis may develop vulvar carcinoma. In advanced cases, skin that has been scarred as a result of Lichen Sclerosis may cause sexual difficulties or problems in passing urine ...
Natural Remedies for Lichen Sclerosus: Insights from Earth Clinic Readers 1. Apple Cider Vinegar (ACV) Many Earth Clinic readers swear by the use ofapple cider vinegarfor its anti-inflammatory and antibacterial properties. Diluting ACV with water and applying it to the affected areas can help redu...
The HPV independent pathway, also known as HPV-independent differentiated VIN (vulvar intraepithelial neoplasia), has been proposed to have lichen sclerosus as a precursor.36 Post-menopausal women with lichen sclerosus are known to have an increase risk of squamous cell cancer of the vulva, but th...
There is an increased risk of developing a skin cancer if LS is not treated. Diagnosis A dermatologist can usually diagnose LS on clinical examination. Sometimes, a dermatologist will perform a skin biopsy to confirm the diagnosis and rule out other conditions. Lichen sclerosus is more common ...
Lichen sclerosus in 68 patients with squamous cell carcinoma of the penis: frequent atypias and correlation with special carcinoma variants suggests a precancerous role. Am J Surg Pathol. 2003;27:1448–53. Article Google Scholar Pietrzak P, Hadway P, Corbishley CM, Watkin NA. Is the ...
ImportanceThe molecular mechanism leading to the development of vulvar squamous cell carcinoma (VSCC) from vulvar lichen sclerosus (VLS) is unknown. ObjectiveTo assess the possible involvement of theIRF6tumor-suppressor gene in the development of VSCC from VLS. ...
What is the risk of developing cancer in patients with lichen sclerosus? Which aspects of lichen sclerosus should be measured to assess response to treatment? Can lichen sclerosus be prevented from occurring and what are the trigger factors?
A new online guide has been launched to support and empower people with vulval lichen sclerosus (LS) to learn about the condition, access the right treatment and live more comfortably. It is estimated that about 1 in 100 women have vulval LS. It can be d