lichen sclerosusvulvar cancercancer riskMalignant potential of lichen sclerosus (LS) has been suspected, but evidence is sparse. We used the population-based Finnish Cancer Registry data to further study this connection.International Journal of Cancer =: Journal International du Cancer...
There is an increased risk of cancer in the long term; women with Lichen Sclerosis may develop vulvar carcinoma. In advanced cases, skin that has been scarred as a result of Lichen Sclerosis may cause sexual difficulties or problems in passing urine ...
patchy skin that appears thinner than normal. Common symptoms include severe itching, discomfort, smooth white spots, blotchy or wrinkled patches, easy bruising, tearing, and pain during intercourse. Timely treatment is essential to prevent complications such as an increased risk of skin cancer and ...
Lichen sclerosus (LS) is a chronic inflammatory disease affecting skin and mucosal tissues, particularly external genitalia, with a risk of cancer. Its etiology is unknown, possibly involving immune dysregulation and inflammation. Methods Study used DNA methylation (DNAme) and single-cell RNA sequencing...
The HPV independent pathway, also known as HPV-independent differentiated VIN (vulvar intraepithelial neoplasia), has been proposed to have lichen sclerosus as a precursor.36 Post-menopausal women with lichen sclerosus are known to have an increase risk of squamous cell cancer of the vulva, but th...
Lichen sclerosus in 68 patients with squamous cell carcinoma of the penis: frequent atypias and correlation with special carcinoma variants suggests a precancerous role. Am J Surg Pathol. 2003;27:1448–53. Article Google Scholar Pietrzak P, Hadway P, Corbishley CM, Watkin NA. Is the ...
Conclusions and RelevanceIRF6dysregulation may be involved in the development of VSCC from VLS. Methylation of theIRF6promoter may be a marker of cancer risk in patients with VLS.
There is an increased risk of developing a skin cancer if LS is not treated. Diagnosis A dermatologist can usually diagnose LS on clinical examination. Sometimes, a dermatologist will perform a skin biopsy to confirm the diagnosis and rule out other conditions. Lichen sclerosus is more common ...
Lichen planus, lichen planopilaris, and lichen sclerosus Lichen planusis an autoimmune disease characterized by an aberrant T-cell cytotoxic reaction against epithelialbasal cells. It can be triggered by medications, drugs, and infectious agents, especially HCV.De novo-onset cases or flares/relapses ...
A new online guide has been launched to support and empower people with vulval lichen sclerosus (LS) to learn about the condition, access the right treatment and live more comfortably. It is estimated that about 1 in 100 women have vulval LS. It can be d