lichen sclerosusvulvar cancercancer riskMalignant potential of lichen sclerosus (LS) has been suspected, but evidence is sparse. We used the population-based Finnish Cancer Registry data to further study this connection.International Journal of Cancer =: Journal International du Cancer...
Lichen Sclerosus is also known as Lichen Sclerosis (or Lichen Sclerosus et atrophicus). It is a painful skin condition that typically affects the vulva (or penis) and anus. It results in white patches on the skin, which causes scarring on and around the genital skin. ...
Lichen sclerosus (LS) is a chronic inflammatory disease affecting skin and mucosal tissues, particularly external genitalia, with a risk of cancer. Its etiology is unknown, possibly involving immune dysregulation and inflammation. Methods Study used DNA methylation (DNAme) and single-cell RNA sequencing...
Lichen sclerosus in 68 patients with squamous cell carcinoma of the penis: frequent atypias and correlation with special carcinoma variants suggests a precancerous role. Am J Surg Pathol. 2003;27:1448–53. Article Google Scholar Pietrzak P, Hadway P, Corbishley CM, Watkin NA. Is the ...
There is an increased risk of developing a skin cancer if LS is not treated. Diagnosis A dermatologist can usually diagnose LS on clinical examination. Sometimes, a dermatologist will perform a skin biopsy to confirm the diagnosis and rule out other conditions. Lichen sclerosus is more common ...
.36 Post-menopausal women with lichen sclerosus are known to have an increase risk of squamous cell cancer of the vulva, but the carcinogenic process is not understood.37 It is also unknown at this time if the same risk is present for children and adolescents diagnosed with lichen sclerosus....
inflammatory infiltrateis present. Colloid bodies may form from degeneratedkeratinocytes. Several investigators have reported an association of lichen planus with vulvar cancer[32,33]. Although the exact risk ofmalignancyis not known, their coexistence with lichen sclerosis suggests a similar risk....
Malignant melanoma in association with lichen sclerosus on the vulva of a 14-year-old. Am J Dermatopathol 1984; 6: 253–6 PubMed Google Scholar McAdams AJ, Kistner RW. The relationship of chronic vulvar disease, leukoplakia, and carcinoma in situ to carcinoma of the vulva. Cancer 1958; ...
ImportanceThe molecular mechanism leading to the development of vulvar squamous cell carcinoma (VSCC) from vulvar lichen sclerosus (VLS) is unknown. ObjectiveTo assess the possible involvement of theIRF6tumor-suppressor gene in the development of VSCC from VLS. ...
Histological changes of lichen sclerosus (LS)—a chronic inflammatory disease—are frequently found in association with squamous cell carcinoma (SCC) of the vulva, suggesting that women with this disorder are at increased risk. However, follow-up studies have been less convincing, showing that the ...