To validate the stem cell status of the Lgr5-expressing CBC cells, a transgenic mouse model was generated with an eGFP reporter gene and a gene encoding a tamoxifen-regulated Cre protein inserted downstream of
we assessed the function of the BMP type I receptor Bmpr1a in intestinal epithelium by crossingBmpr1afl/flmice with the inducibleVillin-CreERT2(Vil-CreER) mice. Five-day tamoxifen