(C) The structure of ISG15 (PDB: 1Z2M) is colored according to the results shown in (B); surface residues that, when altered, did or did not disrupt signaling are indicated in red and green, respectively. (D) ISG15 was assayed for stable association with NK-92 cells. FLAG-ISG15 ...
Results GDF-15 inhibits adhesion of human T cells to activated endothelial cells Assays with anti-coagulated whole blood showed that adhesion of chemokine-stimulated CD45+immune cells on activated human lymphatic endothelial cells (huLEC) is impaired by GDF-15 (Fig.1a). Applying a significance leve...
Hirahashi J, Mekala D, Van Ziffle J, Xiao L, Saffaripour S, Wagner DD, Shapiro SD, Lowell C, Mayadas TN (2006) Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy. Immunity 25: 271–283 PubMed CAS Google Scholar Mayadas TN, Cu...
Altogether, the results indicate that CD18-CD11a integrin, as well as CD11b in mice, may be a useful marker to identify immature stages of NK cell differentiation. 漏 2009 International Society for Advancement of Cytometrydoi:10.1002/cyto.a.20789Loris Zamai...
Results are representative of 3 independent experiments and were similar at 1:25 and 1:12.5 E/T ratios (data not shown). Numbers in each panel correspond to population frequencies. (B) Relative perforin changes in CD56CD8 subsets after target cell mixing. Median fluorescence values were computed...
Results Detaching galectin restores TIL function. We previously analysed human TIL functional responses following stimulation with beads coated with anti-CD3 and anti-CD28 antibodies21,23. To be able to examine the formation of an immunological synapse, we resorted to stimulation with human target ...
Persistent hepatitis B virus (HBV) infection results in chronic liver diseases that may progress to chronic hepatitis, liver cirrhosis, and subsequent hepatocellular carcinoma. Previous studies demonstrated that adaptive immunity, in particular CD8 T cells, is critical in HBV elimination. Recent studies ...
Results: Effector T cell LFA-1 integrin is highly expressed, spontaneously binds ligand, and mediates rapid actin- and calmodulin-dependent adhesion strengthening. Conclusion: LFA-1 in effector T cells binds ligand spontaneously, but firm adhesion requires integrin signaling. Significance: LFA-1 is re...
(1999) Targeting of human dendritic cells by autologous NK cells. J Immunol 163: 6365–6370. [58] Ferlazzo G, Morandi B, D'Agostino A, Meazza R, Melioli G, et al. (2003) The interaction between NK cells and dendritic cells in bacterial infections results in rapid induction of NK cell...
However, these results should be interpreted with caution, as there seems to be functional redundancy among MRL family proteins: Lamaellipodin (Lpd) compensates for the absence of RIAM in Treg to mediate adhesion by LFA1, VLA-4, and α4β7, as double knockout of genes encoding RIAM and ...