by parkinsonism or as dementia complicating established Parkinson's disease. It is unusual both in its pathological features and in its clinical manifestations. Although both overlap to some extent with those of Alzheimer's disease, Lewy body dementia is at least potentially recognizable during life....
Lewy body dementia (LBD) is one of the most common neurodegenerative dementias. Clinical trials for symptomatic and disease-modifying therapies in LBD remain a national research priority, but there are many challenges in both past and active drug developments in LBD. This review highlights the contr...
1. Fresh-frozen cortical brain tissue was used from a cohort of age-matched human subjects, including healthy control subjects (CT, n = 29) and Dementia with Lewy Body patients (DLB, n = 30), who were diagnosed using post-mortem pathology. The tissues were acquired from the ...
A study by NIH researchers has revealed that heart PET scans can predict the likelihood of developing Parkinson’s disease or Lewy body dementia. By analyzing cardiac norepinephrine levels in individuals with Parkinson’s risk factors, the research led by Dr. Goldstein offers a ...
Lewy body disease DLB: Dementia with Lewy bodies PDD: Parkinson’s disease dementia MDS-UPDRS: Movement Disorder Society-Unified Parkinson’s disease rating scale ENS: Enteric nervous system GERD: Gastroesophageal reflux disease MD: Mucosal damage ...
It should be noted that these latest pathological criteria thus moved away from the definition of Lewy body dementia as a disease, and toward the definition of Lewy body dementia as a clinicopathologic entity. Clinical criteria for diagnosis of dementia with Lewy bodies The 2005 report of the ...
Ruffmann C, Calboli FCF, Bravi I, Gveric D, Curry LK, de Smith A et al (2016) Cortical Lewy bodies and Aβ burden are associated with prevalence and timing of dementia in Lewy body diseases. Neuropathol Appl Neurobiol 42:436–450. doi:10.1111/nan.12294 Article CAS PubMed Google Scho...
The genetic basis of Lewy body dementia (LBD) is not well understood. Here, we performed whole-genome sequencing in large cohorts of LBD cases and neurologically healthy controls to study the genetic architecture of this understudied form of dementia, and to generate a resource for the scientific...
Neuroinflammation and Alzheimer’s disease (AD) co-pathology may contribute to disease progression and severity in dementia with Lewy bodies (DLB). This study aims to clarify whether a different pattern of neuroinflammation, such as alteration in microgl
Ruffmann C, Calboli FCF, Bravi I, Gveric D, Curry LK, de Smith A et al (2016) Cortical Lewy bodies and Aβ burden are associated with prevalence and timing of dementia in Lewy body diseases. Neuropathol Appl Neurobiol 42:436–450. doi:10.1111/nan.12294 Article CAS PubMed Google Scho...