Despite its pervasiveness, the concept of 'levels of organization' has received relatively little attention in its own right. I propose here an emerging approach that posits 'levels' as a fragmentary concept situated within an interest-relative matrix of operational usage within scientific practice. ...
Methods for simplifying computer graphics images of atomic models of complex macromolecular assemblies have been applied to the tobacco mosaic virus structure to display different levels of its organization. By constructing sharply outlined pictures of the parts of the virus particle with the image resolu...
Further adjustments for BMI, smoking status, drinking status, education, and physical activity didn't significantly change the risk estimate (OR 0.48, 95% CI 0.42-0.55). Although further adjustment for LDL-C significantly attenuated the association of Lp(a) levels with prevalent MetS, the risk ...
A method of analysing the content of biology curricula, courses, and texts on the basis of the relative emphasis laid on different levels of biological organization, is discussed. It is suggested that this method may have led to unwarranted contrasts between 'traditional' and 'modern' curricula....
Pediocin PA-1 contained an oxygen-sensitivel-methionine residue at position 31, and oxidation of this amino acid residue was known to cause a loss of antimicrobial activity [19]. To overcome this problem, we first followed a previous strategy that had demonstrated increased stability of mutated ...
Fig. 2: Genomic organization of the chromosome 13q14 with CLL-associated genes: two miRNA genes (miR15A,miR16-1) and two lncRNAs (DLEU1andDLEU2). Figure obtained from the Ensembl genome browser. Transcriptomics While genomics is concerned with studying diseases at the DNA level, transcriptomics...
Artificial nighttime lights have important behavioral and ecological effects on wildlife. Combining laboratory and field techniques, we identified behaviorally relevant levels of nighttime light and mapped the extent of these light levels across the city
Here, we use multi-color STED super-resolution microscopy to determine the activity of individual nucleoids in primary human cells. We demonstrate that only a minority of all nucleoids are active. Active nucleoids are physically larger and tend to be involved in both replication and transcription...
Hox proteins have similar binding specificities in vitro, yet they control different morphologies in vivo. This paradox has been partially solved with the identification of Hox low-affinity binding sites. However, anterior Hox proteins are more promiscuo
The Motility pathway group had the highest number of intersections, with 4 pathways intersecting more than 20 of the 27 miRNA (Fig. 4A). The 4 pathways were cell projection morphogenesis, cell projection, plasma membrane bounded cell projection, and cell projection organization. These are all rela...