Changes in the levels of circulating proteins are associated with Alzheimer’s disease (AD), whereas their pathogenic roles in AD are unclear. Here, we identified soluble ST2 (sST2), a decoy receptor of interleukin-33–ST2 signaling, as a new disease-causing factor in AD. Increased circulating...
Puberty is often associated with mood swings and behavioral changes, and approximately 50% of the overall presence of lifetime mental illness has presented before the end of puberty [1]. Early but also late pubertal timing is associated with a higher risk of mental health problems [[2], [3...
Two possibili- ties may account for this observation. First, the regula- tion of HTT by these kinases might be mHTT-specific, i.e., MAPK11 and HIPK3 only regulate mHTT but not wtHTT. Second, the regulation is mHTT-dependent, i.e., both mHTT and wtHTT levels are regulated by ...
This observation is following the hypothesis that excessive TNF production could contribute to the pathogenesis of malaria. Conclusion We may conclude that the TNF level seems to be associ- ated with cerebral malaria by P.falciparum. However, it is still necessary for the development of studies ...
However, in future research and systematic reviews, this observation should be considered. (3) Another limitation related to COVID-19 is the statistical difficulty in knowing whether the observed effects were a product of coronavirus crisis conditions rather than predictor variables. What is certain ...
This allows for an accurate follow-up avoiding duplication of individuals in the database and, most importantly, allows for estimates of accurate rates by dividing the number of events by the number of person-years of observation. Table 1 Population characteristics in Manhiça DSS (1998–2005)...
This allows for an accurate follow-up avoiding duplication of individuals in the database and, most importantly, allows for estimates of accurate rates by dividing the number of events by the number of person-years of observation. Table 1 Population characteristics in Manhiça DSS (1998–2005)...
Blood lipids are heritable modifiable causal factors for coronary artery disease. Despite well-described monogenic and polygenic bases of dyslipidemia, limitations remain in discovery of lipid-associated alleles using whole genome sequencing (WGS), partl
Another noteworthy observation from our study, supported by the results from the BiNGO pathway-based analysis, is that six of the suPAR-associated loci have significant variants in genes encoding proteins that are in some form involved in processes related to glycoprotein biosynthesis or protein glycos...
a. a surveying instrument consisting of a spirit level mounted on a frame with a telescopic sight, used for establishing a horizontal. b. an observation made with this instrument. 17. an imaginary line or sur