Epilogue: New Levels of Complexity in the Functional Roles of Modular Protein Interaction Domains: Switches and Sockets in the Circuit Diagrams of Cellular Systems BiologyIt has not been that long since the modular interaction domains presented in this book appeared merely as multicolored, oddly ...
It is well known that in a given cell, at a particular time, only a fraction of the entire genome is expressed. Expression of a gene, nuclear, or organellar starts with the onset of transcription and ends in the synthesis of the functional protein. The regulation of gene expression is a ...
integrating findings across levels of organismal complexity and using bioinformatic, cell and animal models. Abstract Attention-deficit/hyperactivity disorder (ADHD) is a common and often persistent neurodevelopmental disorder. Beyond gene-finding, neurobiological parameters, such as brain structure, ...
(CC), which provides processed, harmonized and integrated bioactivity data on ~800,000 small molecules. The CC divides data into five levels of increasing complexity, from the chemical properties of compounds to their clinical outcomes. In between, it includes targets, off-targets, networks and ...
Statistical models have been developed for sequence-structure correlations in proteins at five levels of structural complexity: (i) short motifs; (ii) extended motifs; (iii) nonlocal pairs of motifs; (iv) 3-dimensional arrangements of multiple motifs; and (v) global structural homology. We ...
We can only speculate whether these differences led to varying degrees of complexity, which in turn not only tapped visual attention but also further cognitive domains. The relatively large number of erroneous and null responses may substantiate this assumption. We strongly encourage future research to...
more, because venom is also diverse at each level of life, the complexity within the hierarchical structure provides variation that enables powerful analytical approaches to answering questions. As a result, venom provides an excellent model system for understanding big questions in evolutionary biology....
Manyexperimentshaveshownthatlossofbiodiversityreducesthecapacityofecosystemstoprovidethemultipleservicesonwhich2humansdepend1,2.However,experimentsnecessarilysimplifythecomplexityofnaturalecosystemsandwillnormallycontrolforotherimportantdriversofecosystemfunctioning,suchastheenvironmentorlanduse.Inaddition,existingstudiestypically...
As the size and complexity of quantum-dot cellular automata (QCA) digital circuits increase, the amount of time needed to create a QCA layout and then simu... SC Henderson,EW Johnson,JR Janulis,... - 《IEEE Transactions on Nanotechnology》 ...
Logic≠Causationoftheideainapersonorscientificfield. A,B,Calluseandexaltdeduction,thoughtheyuseitdifferently. Examplesoflevels,hierarchies 5 Reductionismrequirestheexistenceofahierarchyoflevels.E.g. Disciplines:PoliticsèSociologyèPsychologyèNeurologyèBiology ...