In vivo, statins may reduce bacteremia and increase bacterial clearance [46,47,48]. Although the exact mechanisms remain unclear, several hypotheses have been proposed. First, statins aid in the production of isoprenoids and lipid compounds, which are essential for pathogen cell signaling and ...
In obesity, excess adipose tissue increases the conver- sion of androstenedione into estrogens, and a reduction in the clearance of estrogen from the blood is also seen in obese women10,11. Higher serum levels of estrogen may lead to infrequent or anovulation. In addition, obesity also causes...
4f, g). GTT and GSIS assays revealed that Nogo−/− mice exhibited both enhanced glucose clearance (Fig. 2c) and insulin secretion (Fig. 2d) compared to WT littermates. Fig. 2: Nogo-B deficiency promotes glucose metabolism and activates the insulin signaling pathway. a A strategy for...
Ethical clearance was obtained for the study. The rats were fed with a formulated basal diet and water ad libitum before the dietary manipulation. Following two weeks of acclimatization, the animals were allocated to two dietary regimens. Six rats were fed only the basal diet (44.4% skimmed mil...
An evaluation of the effects of intermittent sulfadoxine-pyrimethamine treatment in pregnancy on parasite clearance and risk of low birthweight in rural Ma... The prevalence of infection with malarial parasites and the incidence of anaemia and delivery of infants with low birthweight (LBW) were in...
Of the 691 gene-level signals from protein-truncating variants, 99.4% were associated with decreased protein levels. STAB1 and STAB2, encoding scavenger receptors involved in plasma protein clearance, emerged as pleiotropic loci, with 77 and 41 protein associations, respectively. We demonstrate the ...
Production and metabolic clearance of glucose under basal conditions in Type II (non-insulin-dependent) diabetes mellitus Aims/hypothesis: The pathogenesis of fasting hyperglycaemia in Type II (non-insulin-dependent) diabetes mellitus has yet to be clarified. Rates of glucos... J Radziuk,S Pye -...
Muriel Fartoukh, Franck Verdonk, Guillaume Dumas, Alain Tedgui, Bertrand Guidet, Eric Maury, Yannick Chantran, Guillaume Voiriot & Hafid Ait-Oufella Annals of Intensive Care volume 11, Article number: 9 (2021) Cite this article 16k Accesses 63 Citations 46 Altmetric Metrics...
of relatively high levels of environmental210Po in different cadaver tissues in individuals who lived in a large metropolitan city. The accumulation of210Po was higher in the olfactory bulb than in the olfactory epithelium, frontal lobe or lungs, which may be related to the lack of clearance ...
Purpose: Septic patients with hyperlactatemia have increased mortality rates, irrespective of hemodynamic and oxygen-derived variables. The aims of the study are the following: (1) to ascertain whether lactate clearance (LC) (percentage change in lactate over unit time) predicts mortality in septic...