Methods: We measured copeptin and renal function at the Malm Diet and Cancer Cardiovascular Cohort baseline exam and reassessed renal function after a follow-up time of 16.6 卤 1.5 years (n = 3,186). Furthermore, we defined CKD based on an estimated GFR (eGFR) calculated by the ...
Kaplan–Meier curves for new-onset CKD (proteinuria) between 2012 and 2020 according to (A) body mass index (kg/m2) and (B) triglyceride levels (mg/dL). Analysis for all participants. CKD chronic kidney disease Full size image BMI and SBP were associated with an increased risk of GFR ...
However, research on the relationship between the two, SII and BUN, remains understudied in the adolescent population. The purpose of this study was to examine the relationship between SII and BUN levels in a population of American adolescents and to further analyze the factors that influence it....
Based on the findings mentioned above, we hypothesized that CKD and sys- temic inflammation are associated with increasing levels of circulating Cat-S. To test this hypothesis, in a mouse model of progressive CKD and in three clinical cohorts of CKD patients we quantified glomerular filtration ...
To obtain a profound insight into the associated dyslipidemia in CKD, we performed lipidomic analysis to measure lipid metabolites in the serum from a rat 5/6 nephrectomy (5/6 Nx) model of CKD as well as in the serum from CKD patients. HK-2 cells were also used to examine oxidative ...
be measured in the blood or the urine. A more precise measure of kidney function can be estimated by calculating how much creatinine is cleared from the body by the kidneys. This is called creatinine clearance and estimates the filtration rate by kidneys (glomerular filtration rate, or GFR). ...
It has also been reported that increasing blood FLCs concentrations are independently related to an increased likelihood of End-Stage Renal Disease in patients with CKD [12], [26]. A study by De Novellis et al. suggested that the serum free light chain ratio could serve as a biomarker for...
Uptake of Dil- labelled oxLDL was studied by Flow cytometry and a mini- mum of 10.000 cells was analyzed. Determination of estimated glomerular filtration (eGFR) and risk score As a measurement of GFR, we used the estimated GFR (eGFR) using the CKD-EPI formula [14]. For determination Su...
Several studies have documented an association between serum uric acid (SUA) concentration and cardiac hypertrophy in hypertensive patients; however, the association remains unclear in chronic kidney disease (CKD) patients. If there is an association between SUA and hypertrophy in these patients, it is...
urine metabolite concentrations provide an integrative readout of metabolic reactions across tissues and organs17. The study of CKD patients detects genetic effects that usually generalize to population-based samples, but has the added advantage that metabolites normally below the level of quantification ...