Epigenetic editing holds the promise of durable therapeutic effects by silencing disease-causing genes without changing the underlying DNA sequence. In this study, we designed an epigenetic editor to target human PCSK9 and thereby induce DNA methylation at this locus. A single administration of lipid...
"The additional lifelong healthcare cost in this cohort (both children aged four to five and 10 to 11) will amount to £800 million with a cost to society of £8.7 billion." NHS figures released in October showed the proportion of 10 and 11-year-olds who were overweight and...
Vitamin D insufficiency is a common problem worldwide, with a varying prevalence depending on the population of interest and cutoff used to define insufficiency. The medical literature has witnessed an explosion in the number of vitamin D publications over the last three decades, most convincingly su...
Table 7 presents dataset used in our paper [7] to provide different packages of healthcare services in the telemedicine environment. Table 7. formulation of 10 patients’ dataset for evaluating healthcare services provisioning system in telemedicine environment. Patient Alias NameECGrecord namespo2 reco...
Gut microbes are linked to host metabolism, but specific mechanisms remain to be uncovered. Ceramides, a type of sphingolipid (SL), have been implicated in the development of a range of metabolic disorders from insulin resistance (IR) to hepatic steatosi
This study aimed to investigate the relationship between serum lactate levels at admission to the intensive care unit (ICU) and the clinical outcomes of children with sepsis. We used the Pediatric Intensive Care (PIC) database to identify 288 pediatric p
The clinical assessment of the disease stratifications was performed simultaneously as the samples were drawn, i.e. at the emergency room as the patients received initial triage and supportive care. The children enrolled in the study were aged from 3 months up to 6 years. Community controls ...
13With the availability of vaccines for all US residents aged 5 years and older, many public health experts have called for “off-ramps” and “on-ramps” that use available public health data to inform decisions about when to remove or reinstate masking and other mitigation measures.11,12,...
In a previous study, environmental lead contamination was mapped using a multimedia exposure model in the Hauts de France region, which represents 7% of population in the North of France, in part of the population aged 2–70 years old (Caudeville et al., 2012): children were identified as ...
Among this population of pregnant woman and newborns, levels of arsenic measured in blood and urine were lower than national population figures for Canadian women of reproductive age (20–39 years). In general, higher arsenic levels were observed in women who were older, foreign-born (...