39 The strengths of this study include the randomized clinical trial design, sufficient sample size and duration of follow-up to ascertain treatment effects independent of short-term postoperative discomfort and physiological disturbance, systematic recording of adverse events, and low rates of particip...
AHFV = Alkhurma hemorrhagic fever; CCHF = Crimean-Congo hemorrhagic fever; ECMO = extracorporeal membrane oxygenation; KFD = Kyasanur Forest disease; RSSE = Russian spring-summer encephalitis; rVSV = recombinant vesicular stomatitis virus; siRNA = small interfering RNA molecule. Ippolito et al. ...
Remaining patients had oxygenation by mask (13 %), high-flow oxygen therapy (6 %), noninvasive mechanical ventilation (1 %), or nasal cannula (21 %). The mean inspired oxygen fraction (FiO2) in mechanically ventilated patients was 0.46 ± 0.17. Noradrenaline was the only vasopressor ...
In the P450 catalytic cycle, reactive oxygen species (ROS) are formed when activation of molecular oxygen and substrate oxygenation are uncoupled [34]. Cytochrome P450 is a heme-thiolate enzyme in which the distal axial ligand of the heme-moiety is occupied by conserved cysteine residue [35]. ...
Though two trials suggested that ESA use might increase survival (enhanced treatment effects due to increased tumour-cell oxygenation was one postulated mechanism) (Littlewood et al, 2001;Vansteenkiste et al, 2002), several subsequent trials reported that targeting a haemoglobin level of⩾12 g...