translocation of β-catenin. Meanwhile, Zic2 could activate Wnt signaling by interacting with β-catenin. Intriguingly, in HCT116 cells with intrinsic Ser45 mutation of β-catenin, which blocks the degradation-related phosphorylation of β-catenin by CK1, modified Zic2 expression did not affect the...
A common method to identify genomic regions that are associated with traits of interest is to perform genome-wide association studies (GWAS) [8,9]. To date, GWAS have primarily been based on data from single nucleotide polymorphism (SNP) arrays [10,11]. However, while mapping causal variants...
This study was financially supported by the Fundamental Research Funds for the Central Universities (245201971), the Joint Funds of the National Natural Science Foundation of China (U1804106), the Natural Science Foundation of China (81860762), the Qinghai Fundamental Scientific and Technological Resear...
The functional repertoire of the human proteome is an incremental collection of functions accomplished by protein domains evolved along the Homo sapiens lineage. Therefore, knowledge on the origin of these functionalities provides a better understanding
This possibility can be addressed using microscopy to analyze the distribution of cells that are active in conjugation within biofilms. To date, most studies have investigated the spread of the GFP-tagged Pseudomonas putida TOL plasmid. Analysis of P. putida recipient biofilms established in flow ...
Aim: To explore the network relationship between cognitive function, depressive symptom intensity, body composition, proxies of cognitive reserve, trophic factor, adipokines and myokines, physical performance and blood pressure in a group of older people
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