Four animal models with mutations in the glycine receptor's gene support the importance of this subunit in the pathogenesis of hyperekplexia. Three of these are lines of mutant mice with a recessively inherited startle syndrome. In the “spasmodic” mouse, a missense mutation in the α1subunit...
Hyperreflexia, tremor, chorea, and startle responses with myoclonus have been described (Flink, 1985; Cohen and Kitzes, 1987). Common etiologies are parenteral nutrition, acute tubular necrosis, hypoparathyroidism, hyperthyroidism, and hyperaldosteronism. View chapterExplore book Disorders of trace ...
A diagnosis of myelopathy was established based on the presence of hyperreflexia, including a positive Hoffmann sign, upper extremity sensory disturbance and obvious MRI-documented cervical spinal cord compression. Sensory and motor nerve conduction velocities in the peripheral nerves were within normal ...
In these 9 patients, urodynamic studies revealed a change from detrusor hyperreflexia with DESD and high detrusor pressure to almost normal storage and synergic voiding without DESD. The average bladder capacity increased from 258 +/- 33 ml to 350 +/- 49 ml, residual urine decreased from ...