1. a common kind of acute myelogenous leukemia, in which myeloblasts predominate; it usually occurs in infants and middle-aged to older adults. Two types are distinguished; those that have minimal cell differentiation or maturation and those that have more advanced differentiation. Called a...
Typically, CLL is an indolent disease. Adults with low-stage disease with white blood counts less than 30 000/UL do not have any change in life expectancy when compared to age-matched controls without CLL. However, those with more advanced stage disease do not fare as well. Treatment is in...
There are 4 main subtypes of leukemia: acute lymphoid leukemia (ALL), acute myeloid leukemia (AML), chronic lymphoid leukemia (CLL), and chronic myeloid leukemia (CML). ALL and AML progress rapidly and therefore require more aggressive treatment to improve the life expectancy of the patient, wh...
In adults with CML-BP, the response to TKI treatment is very short-lived, and resistance mechanisms independent of BCR::ABL1 often drive progression [53]. Thus, the general principle of reducing the BCR::ABL1-positive cell pool to its minimum over a prolonged period, as applied in CML-CP...
As with younger patients, life expectancy of older adults with CML now approaches that of age-matched controls. Here we review guidelines for management of older adults with CML.doi:10.1016/j.jgo.2018.01.008Luskin, Marlise R.DeAngelo, Daniel J....
Multiple myeloma is a disease typical of the elderly, and, because of the increase in life expectancy of the general population, its incidence is expected to grow in the future. Elderly patients represent a particular challenge due to their marked heterogeneity. Many new and highly effective drugs...
You can expect a near-normal to normal life expectancy if CML goes into remission and you continue to take medicine as prescribed. Not everyone responds to treatment in the same way. Some people will do better than expected. Others will do worse. Factors such as your general health or if ...
Unlike B-ALL, the availability of novel therapeutic options to definitively improve the life expectancy for relapsed/resistant patients is poor. Indeed, the shared expression of surface targets among normal and neoplastic T-cells still limits the efficacy and may induce fratricide effects, hampering ...
Life expectancy of patients with chronic myeloid leukemia approaches the life expectancy of the general population. J Clin Oncol. 2016;34(24):2851-2857. doi:10.1200/JCO.2015.66.2866 PubMedGoogle Scholar 2. Druker BJ, Guilhot F, O’Brien SG, et al; IRIS Investigators. ...
ADLs: Activities of daily life. AML: Acute myeloid leukemia. CGA: Comprehensive geriatric assessment. ECOG=Eastern Cooperative Oncology Group. HCT: Hemopoietic cell transplantation. ICT: Intensive chemotherapy. NRM: Non-relapse mortality. Standard AML therapy for adults: the one that would receive a ...