Many of these adverse events resolve over time or after a brief drug holiday. A dose reduction may be considered in patients who achieved an MMR [50]. Dasatinib Dasatinib is a 2GTKI, more potent than imatinib and active against several imatinib-resistant BCR-ABL1 mutants (Table 5). The ...
Improved survival of men 50 to 75 years old with acute myeloid leukemia over a 20-year period.doi:10.1182/blood.2019001728Blood
23 Indeed, PTH can directly stimulate the proliferation and survival of HSPC, but it also partially exerts its effects through the OB24 by increasing the production of Jagged 1 in OB, which in turn activates Notch receptors on nearby HSPC. Moreover, PTH has also been shown to act through ...
Radioactive iodine (RAI, 131I) has been used as a therapeutic agent for differentiated thyroid cancer (DTC) with over 50聽years of history. Recently, it is... T Higashi,T Kudo,S Kinuya - 《Annals of Nuclear Medicine》 被引量: 30发表: 2012年 Chronic myeloid leukemia in a man with pap...
Pharmacologic targeting of chromatin-associated protein complexes has shown significant responses in KMT2A-rearranged (KMT2A-r) acute myeloid leukemia (AML) but resistance frequently develops to single agents. This points to a need for therapeutic combin
For over 50 years the received wisdom has been that the shadow cells of Gumprecht otherwise known as basket cells (BC) are in artefact, produced during preparation of films when a drop of blood is spread on a slide. The assumption has been that they are therefore of no significance. They...
Chronic lymphocytic leukemia (CLL) most often affects adults over the age of 55. It sometimes occurs in younger adults, but it almost never affects children. Two-thirds of affected people are men. The five-year survival rate is 75%.
1. A method of treating chronic lymphocytic leukemia in an individual, comprising the step of administering a therapeutically effective amount of a selecticine to the individual. 2. The method of claim 1, wherein the selecticine is selected from the group consisting of selenocystine, selenocyste...
Moxetumomab pasudotox-tdfk solution is to be infused over 30 min. Prior to each infusion, patients over 50 kg should receive 1 L of hydration with an isotonic IV solution (e.g. 5% dextrose injection, 0.45% or 0.9% sodium chloride injection) over 2–4 h. For patients under 50 kg,...
This effect was particularly pronounced in patients with lower IFNγ production before therapy (supplemental Figure 1C; P < .01). Finally, we evaluated programmed death 1 expression on CD4+ T cells as a feature of T-cell exhaustion.50 The level of programmed death 1 expression on T cells ...