In adults: Chronic phase of CML 400mg/day orally Accelerated phase of CML 600mg/day orally Blastic transformation of CML 600mg/day orally 2. In children: Chronic phase of CML 340mg/m2/day orally. Frequency of Monitoring Response to Imatinib ...
In adults with standard-risk acute lymphoblastic leukemia, the greatest benefit is achieved from a matched sibling allogeneic transplantation in first complete remission, and an autologous transplantation is less effective than conventional consolidation/maintenance chemotherapy in all patients: final results ...
Due to the further introduction of all- trans retinoic acid (ATRA) and—more recently—the development of arsenic trioxide (ATO)-containing regimens, APL is currently the most curable form of AML in adults. Treatment with these new agents has introduced the concept of cure through targeted ...
Lin-wei Xu Yong-zhong Su Hong-fang Tao Current Medical Science (2021) Second cancers in adults with acute promyelocytic leukemia treated with or without arsenic trioxide: a SEER-medicare analysis Kelly J. Norsworthy Armen Avagyan David J. Graham Leukemia (2020)Download...
Fig. 1: Overall survival data among 1123 consecutive adults with non-APL acute myeloid leukemia (AML). aAnalysis stratified by calendar year of diagnosis.bAnalysis stratified by AML subcategories.cAnalysis stratified by treatment received.dAnalysis stratified by response obtained (limited to patients ...
99% in children, and the median duration of remission was only 24 months in the adults, whereas it has not yet been reached in the children and is projected to be over 4 years. In AML and the related nonlymphoblastic forms of acute leukemia, therapy is still unsatisfactory in both adults...
This phase III, randomized trial in previously untreated adults with ANLL compared mitoxantrone plus cytosine arabinoside with the CALGB "7 + 3" daunorubic... Z Arlin,Case DC,J Moore,... - 《Leukemia》 被引量: 242发表: 1990年 Allogeneic marrow transplantation using fractionated total body irr...
Acute lymphoblastic leukemia (ALL) is the second most common acute leukemia in adults, with an incidence of over 6500 cases per year in the United States alone. The hallmark of ALL is chromosomal abnormalities and genetic alterations involved in differentiation and proliferation of lymphoid precursor...
1 and annually, more than one quarter of a million adults throughout the world are diagnosed with AML,3 with 60% being over 60 years of age.4 . Although it represents the most common type of leukemia in adults, it continues to have the lowest survival rate of all.5 In fact, two-...
Most frequent is the t(4;11)/MLL-AF4, which is mainly found in pro-B cell ALL and occurs in adults at a higher frequency than in children [6]. The MLL protein is a nuclear protein that maintains the expression of particular members of the HOX family. Leukemia associated translocations ...