The structure of the leucine, isoleucine, valine-binding protein, an integral part of the high-affinity, branched-chain aliphatic amino acid transport system in Escherichia coli, has been solved at 3.0-A resolution by x-ray crystallography. Five isomorphous heavy atom derivatives, including anomalous...
Leucine and Isoleucine are two amino acids that differ only by the positioning of one methyl group. This small difference can have important consequences in & alpha;-helices, as the & beta;-branching of Ile results in helix destabilization. We set out to investigate whether there...
isoleucine, tyrosine,phenylalanineandtryptophan. A problem may arise when these amino acids compete with one another for sites on the transporter molecule to be carried into the brain. If there is an overabundance of leucine, this could result in the others being pushed out of transport spots ...
They also support the idea that the isoleucine residue is one of the most powerful candidates for -structure formation, and they show that the unbranched norleucine residue has intermediate properties. The results are discussed on the basis of steric and hydrophobic properties of the three side ...
Small-angle x-ray scattering and computer modeling have been used to study the effects of ligand binding to the leucine/isoleucine/valine-binding protein, an initial component of the high-affinity active transport system for branched-chain aliphatic amino acids in Escherichia coli. Measurements were ...
Refined X-ray structures of the leucine/isoleucine/valine-binding protein and its complex with leucine. The three-dimensional structure of the native unliganded form of the Leu/Ile/Val-binding protein ( M r = 36,700), an essential component of the high-affini... JS Sack,MA Saper,FA ...
We measured the Ac-Leu, and its structure is similar to N-acetyl isoleucine (Ac-Ile) in human hair by ultra-performance liquid chromatography (UPLC) with electrospray ionization tandem mass spectrometry (ESI–MS/MS). The developed method was applied to the determination of Ac-Leu and Ac-Ile...
Crystal environ- ments and geometries of leucine, isoleucine, valine, and phenylal- anine provide estimates of minimum nonbonded contact and preferred van der Waals interaction distances. J Am Chem Soc 1985;107:5921-5927.R. O. Gould, A. M. Gray, P. Taylor and M. D. Walkinshaw, J. Am...
Leucine: Proline: Isoleucine (2:1:1) structure CAS No. Chemical Name: Leucine: Proline: Isoleucine (2:1:1) Synonyms CBNumber: CB72515123 Molecular Formula: Molecular Weight: 0 MDL Number: MOL File: Mol file Request For Quotation Leucine: Proline: Isoleucine (2:1:1) Preparation Products ...
it was seen that in a synthetic mixture of 13 amino-acids (Hoffmann-LaRoche, mostly in the l-configuration) the `methionine' recovery was always too high (120-150 per cent of the theoretical amount) and the `isoleucine' recovery always too low (65-70 per cent of the theoretical amount)...