Met/Leu enkephalins also function in pain perception and response to stress. MSH increasedmelanin production in melanocytes which leads to an increase in skin pig-mentation. Leumorphin may be important in apoptosis prevention by being involved in the MAPK and PI 3-K pathways.Met/Leu-enkephalin...
N/OFQ is a 17-aa peptide with aphenylalanineat the N-terminus and a glutamine at the C-terminus, and the peptide was originally termed OFQ because of this structural characteristic. The other original name N was derived from its physiological function. The N terminal 4-aa residue sequence ...
R. Mitchell Molecular aspects of central neurotransmitter function E. Flückiger, E.E. Müller, M.O. Thorner (Eds.), Transmitters Molecules in the Brain, Springer-Verlag, Berlin (1987), pp. 37-45 CrossrefGoogle Scholar Mize et al., 1991 R.R. Mize, C.J. Jeon, G.D. Butler, Q. Lu...
Except for the brain, the physiological function of NEP in various tissues remains largely unknown, but this ectoenzyme is likely involved in inactivation ... N Sales,I Dutriez,B Maziere,... - 《Regulatory Peptides》 被引量: 70发表: 1991年 Neutral endopeptidase (EC 3.4.24.11) in labial...
Effects of leu-enkephalin and dalargin on cardiac function in rats under conditions of low-frequency stimulation of postganglionic sympathetic fiberspostganglionic sympathetic fibersleu-enkephalindalarginlow-frequency stimulationcardiac actionLeu-enkephalin inhibits and dalargin has no significant effect on the...
The specific activity of the enzyme in synaptosomal membranes measured with tertiary-butoxycarbonyl-Phe-Ala-Ala-Phe- p -aminobenzoate as substrate was higher than that of endo-peptidase-24.11 ("enkephalinase"), a membrane-bound zinc-metalloendopeptidase believed to function in brain neuropeptide ...
We and others have demonstrated that impaired arterial baroreceptor reflex (ABR) function is one of the major causes of hypertension-associated end organ damage. The goal of this study was to clarify the potential neuro-humoral mechanisms responsible for impaired ABR-induced end organ damage. The ...
Some unexpected side-reactions were encountered during the synthesis of the linear precursors: partial cleavage of the active ester during removal of the Bocprotecting group, partial cleavage of the Gly-Gly peptide bond during hydrazinolysis of an ester function and failure to obtain the p-...
Inflammatory reaction may be improved by DADLE by regulating the infiltration of inflammatory cells in the liver and kidney and regulating the cognitive function of the brain and the ageing of the heart in mice.doi:10.1007/s12035-024-04503-yHuo, Lixia...
2. 2. The greatest activity of met- and leu-enkephalin-like immunoreactivity in earthworm gut appears in regions of high digestive enzyme activity and gastrin-like immunoreactivity where it presumably plays a role in regulation of gut function. 3. 3. In all tissues studied the levels of met-...