For example, pharmacological targeting of two components of a single signaling cascade, ATR and CHK1, confers cancer-specific lethality [45]. This seemingly counterintuitive strategy relies on the fact that ATR and CHK1 have unique unrelated functions (see Figure 1B and main text for details). ...
Thirty cases, for whom longitudinal personality data were available from 1921 to 1960, were analyzed. All the cases were Caucasian males with high I.Q.'s. Five individuals had committed suicide (all by gunshot), 10 (matched) individuals had died natural deaths from cancer or heart disease, ...
- 《Cancer Research》 被引量: 155发表: 1985年 Conditional expression of the ErbB2 oncogene elicits reversible hyperplasia in stratified epithelia and up-regulation of TGFα expression in transgenic mice. However, perinatal lethality precluded the establishment of a transgenic line for analysis of ErbB...
Nat. Rev. Cancer 16, 494–507 (2016). Article CAS PubMed Google Scholar Degryse, S. et al. Mutant JAK3 phosphoproteomic profiling predicts synergism between JAK3 inhibitors and MEK/BCL2 inhibitors for the treatment of T-cell acute lymphoblastic leukemia. Leukemia 32, 788–800 (2018). ...
Genotypes causing pregnancy loss and perinatal mortality are depleted among living individuals and are therefore difficult to find. To explore genetic causes of recessive lethality, we searched for sequence variants with deficit of homozygosity among 1.5
This swainsonine coadministration treatment regimen has been identified previously in our laboratory as the superior of the two optimal conditions for diminishing lethality in mice due to LD50/14 doxorubicin. The anthracycline, doxorubicin is a potent and widely used cancer chemotherapeutic agent whose ...
These data support a role for PI3K-AKT pathway activation in kidney tumor formation caused by loss of BHD and suggest that inhibitors of both mTORC1 and mTORC2 may be effective as potential therapeutic agents for BHD-associated kidney cancer. 展开 关键词: Birt-Hogg-Dube syndrome kidney cancer ...
suggesting a role in heart development51. The differentially expressed (DE) genes responsible for the GO term annotations are mainly associated with neuronal function (Fig.5c). For example, transcripts of three genes coding for synapse-locatedSlitrkproteins52, whose human homologues are associated wi...
Ripk1−/−ripk3−/−casp8−/− and ripk1−/−ripk3−/−fadd−/− mice gained weight over time and appeared similar to their littermates for several months (Figures 1D–1G). Formally, then, the ripk1 gene inhibits perinatal lethality dependent on ripk3 and either ...
(n = 16 mice distributed asn = 8 for 2 DPI andn = 8 for 4 DPI) mice were similarly infected and killed at 2 and 4 DPI and viral titers in different organs (nasal turbinate, trachea, lung, brain, heart, kidney, liver, spleen, small intestine, and large intestine) ...