ATR/CHK1 inhibitors, able to block such response, could potentiate the effects of cytotoxic drugs or radiation therapy, increasing tumor cells’ death in p53-deficient scenarios. ATR inhibitors, for instance, stall replication forks and cause chromosomal breakage, sensitizing tumors to DNA-damaging ...
The neutrons were unac颅companied by gamma-radiation, and stray X-rays were excluded by 5 mm. of lead surrounding the specimens. The dose was measured and converted into energy units in the manner already described.doi:10.1038/144478b0L. H. GRAY...
Again, in particular embodiments the lethal phenotype may be apoptosis, necrosis or growth arrest. In other particular embodiments, the secondary reagent may be UV, X-ray or neutron radiation, or may be a chemotherapeutic agent, more particularly methotrexate, cisplatin, 5-fluorouracil, colchicines,...
radiations and die by apoptosis or mitotic death. in addition, ir induces microvascular damages due to endothelial cell apoptosis and an important inflammatory response in the intestine, characterized by inflammatory cell infiltration and an overproduction of pro-inflammatory mediators contributing to ...
dose ionizing radiation (IR)1,2. A dose of 15 gray (Gy) of radiation is sufficient to abrogate the proliferative output of these mitotically activeLgr5highISCs, and thus causes severe acute damage of the epithelial integrity2. Within 7 days of high-dose IR exposure, mice suffered from ...
a Heatmap of genes in combined MSigDB interferon gene sets. b Forty-eight interferon response genes were significantly altered (FDR < 0.1) in C/EBPβ-depleted tumors. The light gray circle represents genes overlapping with C/EBPβ−/− epidermis and the below gene list shows significant...
Tumor boundaries and critical organs were contoured manually. The full dose of radiation exposure was decided according to the risk assessment of the biopsy proven cancer stage from the near to the distant tumor margin and the critical value of the organ. Radiation was delivered with 70, 63, an...