Ahmed M. Acute toxicity (Lethal Dose 50 Calculation) of herbal drug Somina in rats and mice. Pharmacol Pharm 2015;6:185-9.Ahmed, M. (2015). Acute Toxicity ( Lethal Dose 50 Calculation ) of Herbal Drug Somina in Rats and Mice. 3(3):185-189.Ahmed M. Acute toxicity (Lethal Dose ...
(ED50) developed by Spearman and Karber with ideal median lethal dose (IMLD50) formula developed by Saganuwan with a view to bringing out their difference and similarity in calculation of ED50that could be used to develop a new median lethal dose formula for calculation of Micrarus fulvius ...
Then, the mortality of the Artemia salina was evaluated using a probit analysis [16] which was based on the dose-response curves to determine the [LC.sub.50] (lethal concentration of rotenone in rotenoids resin). Biological activity on the extract of Derris elliptica: an optimization approach...
关键词 : 鼠疫 ; 毒力 ; 半数致死量(LD50 ) 中图分类号 : R378文献标识码 : B文章编号 : 1002 -2694(2013)11 -1127 -04Calculation of median lethal dose (LD50) forYersinia pestis by SPSS packageXIONG Hao‐ming , WEI Bai‐qing , WEI Rong‐jie , YANG Ning‐hai ,QI Mei‐ying , JIN ...
calculation of the lethal dose of 50% for BALB/c mice (LD50) were performed as described [28]. The end-points were weight loss of 40% of the initial weight and/or the inability to respond to the righting reflex. Animals that reached these predetermined end-points were humanely sacrificed....
maximum non-lethal dose (MNLD)Highest single dose which does not induce death in animals; has replaced calculation of LD-50?? values.doi:10.1007/978-3-211-89836-9_825Gerhard NahlerClinical Investigation Support PharmaforschungSpringer Vienna
Additionally, the high but sub-lethal dose of radiation used leads to significant lymphopenia [37]. The sudden reduction in lymphocyte number may create the spatial allowance in spleen and lymph nodes necessary for the homing, activation and expansion of he adoptively-transferred T cells. The ...
One might argue to make the test duration 48 h or 24 h from the perspective of internal dose. For substances that are actively taken up through transport pathways in the gills, such as Na+, it might take as little as 30 s for the substance to appear in the blood (Handy and ...
dose of virus. Injection of 0.4 µg TNF led to similar ALT levels as seen with a OT-I T cell-mediated hepatitis and half of the infectious dose of AdGOL. Notably, despite high ALT levels, TNF-treated animals never developed fulminant hepatitis or succumbed to death (Fig.4b). As ...
“average effect” calculation, we applied a terrace ranking method (Fig.2a, b) as follows: after filtering out all the noisy reads, we calculated the “drug/control” ratio for all the individual SGRs in the library using the following equation: (normalized number of SGR reads in drug-...