Since 1972, Jay Forrester and colleagues at MIT have been evolving the System Dynamics National Model (SDNM). The purpose of this model is to guide policy makers in dealing with today's major problems. The ambitious scope of the project motivates careful examination of modeling practices and ...
As well as the challenge of modelling the dynamics of the system, there are two major issues in applying a particle filter to such a model. The first is the asynchronous nature of the system-observations from different subsystems arrive at different rates, and occasionally out of order, ...
The first HF computer modeling study by Priebe and Beuckelmann [21] showed how spontaneous Ca2 + release from the sarcoplasmic reticulum can trigger a premature action potential in single failing myocytes but not in normal myocytes, due to a greater INCX. However, DADs are not likely to ...
et al. Metabolic modeling of a mutualistic microbial community. Mol. Syst. Biol. 3, 92 (2007). An early example of the extension of flux balance modelling to a microbial community. Article PubMed PubMed Central CAS Google Scholar Walker, C. B. et al. The electron transfer system of ...
Complex systems exhibit dynamics across multiple timescales. Strong couplings across timescales can be important, but common practice has been to ignore the couplings. This paper describes my experience modeling electric power systems when clients argued for models including both fast and slow dynamics. ...
Post-Hoc Pattern-Oriented Testing and Tuning of an Existing Large Model: Lessons from the Field Vole 来自 学术范 喜欢 0 阅读量: 57 作者:CJ Topping,D Trine,G Volker,B Louis-Felix 摘要: Pattern-oriented modeling (POM) is a general strategy for modeling complex systems. In POM, multiple ...
Many studies in the past decade have revealed the role and mechanisms of Wnt signaling in axon guidance during development and the reinduction of Wnt signaling in adult central nervous system axons upon traumatic injury, which has profound influences on axon regeneration. With 19 Wnts and 14 know...
4). Early serial serological data and information from the literature on the relative hospital hazard ratio of each VOC were essential to capture the observed dynamics. Subsequently, the model extrapolated the temporal burden of disease in the Belgian population, estimating a total of 8.9 million ...
The rapid development of COVID-19 vaccines and their deployment in less than a year is an unprecedented scientific, medical, and public health achievement. This rapid development leveraged knowledge from decades of HIV/AIDS research and advances. However
Responding quickly to unknown pathogens is crucial to stop uncontrolled spread of diseases that lead to epidemics, such as the novel coronavirus, and to keep protective measures at a level that causes as little social and economic harm as possible. This