How does Leqvio work (mechanism of action)? Leqvio works by shutting down production of an enzyme in the body called PCSK9. This enzyme breaks down receptors in the liver that help remove bad cholesterol (LDL-C) from the blood. By blocking production of the PCSK9 enzyme, the receptors in...
12.1 Mechanism of Action Inclisiran is a double-stranded small interfering ribonucleic acid (siRNA), conjugated on the sense strand with triantennary N-Acetylgalactosamine (GalNAc) to facilitate uptake by hepatocytes. In hepatocytes, inclisiran utilizes the RNA interference mechanism and directs cataly...
However, target LDL-C levels continue to be lowered. Specifically, the goal of maintaining LDL-C at or below 55 mg/dL was established because several clinical studies have shown evidence that LDL-C reduction provides additional clinical benefit. With the recent increase in the use of PCSK9 inh...
Mechanism Of Action Inclisiran is a double-stranded small interfering ribonucleic acid (siRNA), conjugated on the sense strand with triantennary N-Acetylgalactosamine (GalNAc) to facilitate uptake by hepatocytes. In hepatocytes, inclisiran utilizes the RNA interference mechanism and directs catalytic b...
How does Leqvio work (mechanism of action)? Leqvio works by shutting down production of an enzyme in the body called PCSK9. This enzyme breaks down receptors in the liver that help remove bad cholesterol (LDL-C) from the blood. By blocking production of the PCSK9 enzyme, the receptors in...